- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Studies on the Safety of Artemisiae Capillaris Herba - With the Perinatal and Lactational Reproductive Toxicity -
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.2, pp.32-51
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(2005). Studies on the Safety of Artemisiae Capillaris Herba - With the Perinatal and Lactational Reproductive Toxicity -. Journal of Korean Medicine, 26(2), 32-51.
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Abstract
Objectives : The effect of Artemisiae capillaris herba Extracts that have been used as oriental medicine to the liver disease on the perinatal and lactational reproductive toxicity of SD rats when administered by oral gavage. Methods : Female SD rats were dosed from 6 days of gestation to 3 weeks of postpartum. It was conducted in accordance with the recommendations of the KFDA Guideline for Detection of Toxicity to Reproduction for Medicinal Products. Results : No Artemisiae Capillaris Herba extracts treatment-related changes of clinical signs, mortalities, implantation number, dead fetus number, loss rate of fetus, number of live youngs, survival rate of fetus, sex ratio of live youngs, external anomalies, pregnancy periods, viability index, lactational index, survival rate of litters at 4 days after birth and delivery index were demonstrated in all dosed levels in this study. Although the body weight and gains, food consumption and absolute organ weights of brain, adrenal glands, liver, spleen, kidney, ovaries and heart were significantly increased in 2000 or 1000㎎/㎏-dosing groups and the relative organ weights of adrenal glands were significantly increased in 2,000㎎/㎏-dosing groups. So it was concluded that this increase was natural according to the growth. And no changes of gross findings, clinical signs, mortalities, body weight and gains, physical development results, necropsy findings, organ weight, Faculty test, open filed test and water- filled simple T-maze test, copulation, fertility, pregnancy indices, body weight and gains during gestation periods, necropsy findings, corpora lutea number, implantation number, implantation rate, dead fetus number, post-implantation loss rate, live youngs, post- implantation survive rate, sex ratio of live youngs, external anomalies and individual body weights of live youngs were demonstrated in all dosed levels in this study. Conclusions : It is considered that the NOAEL(No-Observed-Adverse-Effect Level) for perinatal and lactational reproductive toxicity of Artemisiae Capillaris Herba Extracts was up to 2000mg/kg/day because there no changes of other perinatal and lactational reproductive index were demonstrated.
- keywords
- Artemisiae Capillaris Herba, KFDA Guideline, Perinatal and lactational reproductive toxicity., Artemisiae Capillaris Herba, KFDA Guideline, Perinatal and lactational reproductive toxicity.
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