Article Detail

Home > Article Detail
  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

The protective effects of Geupunggibodan on brain damage and cognitive dysfunction in transient focal cerebral ischemia in rats

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.2, pp.52-62



  • Downloaded
  • Viewed

Abstract

Objectives: This study was conducted to determine the effects of Geupunggibodan on brain damage in transient focal cerebral ischemia in rats. Methods: Rats were used for testing in the following three models: Morris Water Maze, Eight-Arm Radial Maze, and Histochemistry. Results: In the Morris Water Maze Model, the Geupunggibodan group showed significant decrease in the the 3rd, 4nd and 6th training session compared with the ischemia group. A retention test, in the Morris Water Maze Model, was performed on the 7th day without the escape platform. The Geupunggibodan group showed significant increase compared to the ischemia group. In the Eight-Arm radial Maze model, the Geupunggibodan group showed significant decrease in the error rate compared to the ischemia group. In the density of hippocampal CA1 cell of the cresyl violet-stained section, the Geupunggibodan group showed significant increase compared to the ischemia group. Conclusions: These results suggest that Geupunggibodan may have a significant protective effect on brain damage and cognitive dysfunction in transient focal cerebral ischemia.

keywords
transient focal cerebral ischemia, Geupunggibodan, transient focal cerebral ischemia, Geupunggibodan


Reference

1

(1997) 해리슨내과학, 도서출판정담

2

(1990) Hypothermia but not the N-methyl-D-aspartate receptor antagonist attenuates neuronal damage in gerbils subjected to transient global ischemia,

3

(2003) 사물탕가미방이 중대뇌동맥폐쇄에 의한 뇌허혈손상에 미치는 영향, 동의대학교 대학원

4

(2001) 흰쥐의 중대뇌동맥 결찰로 유발된 뇌허혈에서 성향정기산과 곽향정기산이 신경세포에 미치는 효과, 동국대학교 대학원

5

(2000) 양격산화탕이 뇌혈류 및 뇌허혈 손상에 미치는 영향, 경희대학교 대학원

6

(2000) 방풍당귀음이 중대뇌동맥 폐쇄 후 재관류 모델에 미치는 영향, 동국대학교 대학원

7

(1998) 東醫方劑와 處方解說, 의성당

8

(2000) 祛風至寶丹의 Mongolian Gerbil의 가역성 전뇌허혈 모델에 미치는 영향, 동국대학교 대학원

9

(2001) 祛風至寶丹의 혈관이완효능과 기전에 관한 연구, 동국대학교대학원

10

(1989) Reversible middle cerebral artery occlusion without craniectomy in rats.Stroke,

11

(1986) The rat brain in stereotaxic coordinates, Academic Press

12

(1987) The third generation of progress, New York Press

13

(1988) Reevaluation of the contribution of the basal forebrain cholinergic system to memory.Neurobiology of Aging,

14

(1989) In vivo modulation of septohippocampal cholinergic in mice Relationships with spatial reference and working memory performance,

15

(1989) The role of the fomix/fimbria and some related subcortical structures in place learning and memory.Behavioral Brain Research,

16

(1977) 三因極一病證方論,

17

(1997) 調胃升淸湯이 흰쥐의 방사형 미로 학습과 기억에 미치는 영향,

18

(1998) 荊防地黃湯이 Alzheimer's disease 모델백서의 학습과 기억에 미치는 영향,

19

(1999) 星香正氣散이 NOS Inhibitor 투여에 의한 백서의 학습 및 기억장애에 미치는 영향,

20

(1990) Hypothermia but not the N-methyl-D-aspartate receptor antagonist attenuates neuronal damage in gerbils subjected to transient global ischemia,

21

(1995) ameliorates the impaired memory of rat in the Morris water maze,

22

(1991) Spatial performance correlated with in vitro potentiation in young and aged Fisher 344 rats,

23

(1996) Use of the Morris water maze and acoustic stratle chamber to evaluate neurologic injury after asphyximal arrest in rats,

24

(1993) Spatial guidance of choice behavior in the radial-arm maze,

25

(1994) Enhancement of memory processing in an inhibitory avoidnace and radial maze task by post-training infusion of bombesin into the nucleus tractus solitarius,

26

(1989) The role of the hippocampal-nucleus accumbens pathway in radial-arm maze performance,

27

(1993) Spatial guidance of choice behavioral in the radial-arm maze,

28

(1996) Effect of gestational and lactational exposure to TCDD or coplanar PCBs on spatial learing,

29

(1995) Effect of subchronic exposure to toluene and reference memory in rats,

30

(2000) American Journal of Chinese Medicine,

  • Downloaded
  • Viewed
  • 0KCI Citations
  • 0WOS Citations

Other articles from this issue

Recommanded Articles

상단으로 이동

Journal of Korean Medicine