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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Chunghyul-dan for the prevention of stroke progression in silent brain infarction

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.2, pp.77-84








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Abstract

Objectives: Chunghyul-dan is a combinatorial herbal medicine, and previous studies reported it had therapeutic effects for microangiopathy, which is a major part in the progression of stroke, as having anti-hypertensive, anti-hyperlipidemic, anti-apoptotic, anti-oxidative, and anti-inflammatory activities. Therefore, we examined the inhibitory effect of Chunghyul-dan on stroke occurrence in patients with silent brain infarction. Methods: We prescribed Chunghyul-dan 600 mg a day to the patients with silent brain infarction confirmed by brain MRI, and monitored stroke occurrence, drug compliances, and adverse effect for 1 year. And then we performed follow-up brain MRI to find new vascular lesion after 1 year of Chunghyul-dan medication. As for the subjects lost to follow-up, we assessed their prognosis after 1 year by telephone. Results: There were twenty one subjects who had been treated with Chunghyul-dan for more than 1 year. None of them experienced new clinical syndrome characterized by rapidly developing clinical symptoms and signs of focal and at times global loss of brain function, which could be accompanied with evidence of stroke occurrence, and any of adverse effects during Chunghyul-dan medication period. These results might be explained by various biochemical effects of Chunghyul-dan on microangiopathy, which is closely related with cell cycle progression, hypertension, hyperlipidemia, vascular inflammation, and oxidative damage. Of the 10 subjects lost to follow-up, six could be connected with us. And two of them had stroke occurrence. Conclusions: We suggest Chunghyul-dan could be useful for prevention of stroke occurrence in the patients with silent brain infarction by preventing the progression of microangiopathy. Further study with a randomized controlled trial is needed to confirm this suggestion.

keywords
Chunghyul-dan, Silent brain infarction, Stroke Prevention, Chunghyul-dan, Silent brain infarction, Stroke Prevention


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