- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Mechanisms of Apoptosis by Combination with Jeongjihwan and Cisplatin in Human Glioblastoma Cells
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.2, pp.1-12
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(2005). Mechanisms of Apoptosis by Combination with Jeongjihwan and Cisplatin in Human Glioblastoma Cells. Journal of Korean Medicine, 26(2), 1-12.
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Abstract
Objectives : Malignant gliomas are often treated with cisplatin (cis-diaminedichloroplatinum (II), CDDP) and radiation but results remain unsatisfactory. Since malignant glioma displays moderate resistance to conventional therapy, a new treatment modality is needed to improve the outcome of patients with these tumors.The aim of this study was to investigate the effects of the combined use of Jeongjihwan(JJH) and cisplatin (CDDP) on cultured malignant glioma cells, A172.Method & Results : The combined use of cisplatin and Jeongjihwan had synergistic effects on A172 cells during 24 hr-incubation. This treatment resulted in decrease of cell viability, which was revealed as apoptosis characterized by activation of caspase-3 protease as well as cleavage of poly ADP-ribose polymerase (PARP) with change of mitochondrial membrane potential transition. The expression of members of the Bcl-2 protein family was modulated during co-treatment with Jeongjihwan and cisplatin. Activation of caspase-3 and mitochondrial alterations were central to co-treatment with Jeongjihwan and cisplatin-induced apoptosis.Conclusion : We conclude that co-treatment with Jeongjihwan and cisplatin-induced activation of the mitochondrial pathway enables cell death. Also, we suggest the combined theory of JJH and cisplatin could be a useful method for glioblastoma.
- keywords
- Jeongjihwan, Apoptosis, Human Glioblastoma Cells
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