- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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The Effects of Oryungsan-gagampang on leptin level, leptin receptor level and differentiation of 3T3-L1 adipocyte
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.2, pp.241-251
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(2005). The Effects of Oryungsan-gagampang on leptin level, leptin receptor level and differentiation of 3T3-L1 adipocyte. Journal of Korean Medicine, 26(2), 241-251.
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Abstract
Objective : This experimental study was designed to investigate the effects of Oryungsan-gagampang on leptin, leptin receptor level and differentiation of 3T3-L1 adipocyte. Methods : After 3T3-L1 adipocytes were incubated with various concentrations of Oryungsan-gagampang and Reductil?? for 7 days, leptin and leptin receptor level in 3T3-L1 adipocytes were measured by ELISA. To elucidate the mechanism of inhibitory effects of Oryungsan-gagampang on obesity, the 3T3-L1 adipocytes after Oil Red O staining were taken by digital photo system. Results : 1. Oryungsan-gagampang 1,000 ㎍/㎖ significantly increased leptin level in 3T3-L1 adipocytes in comparison with control group (p<0.05), and Oryungsan-gagampang 0.1 10, 1,000 ㎍/㎖ significantly increased leptin receptor level in 3T3-L1 adipocytes in comparison with control group (p<0.05). 2. Oryungsan-gagampang inhibited of differentiation of 3T3-L1 adipocytes. Conclusions : Oryungsan-gagampang showed significant effects on inhibiting differentiation of 3T3-L1 adipocytes, and increasing leptin level and leptin receptor level in 3T3-L1 adipocytes. Therefore, Oryungsan-gagampang can be used to treat obesity, but further studies are required.
- keywords
- Oryungsan-gagampang, obesity, 3T3-L1 adipocyte, leptin, leptin receptor, differentiation, Oryungsan-gagampang, obesity, 3T3-L1 adipocyte, leptin, leptin receptor, differentiation
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