- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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The Effects of Danchunwhangagam on LPS or DFX-induced Cytokine Production in Peripheral Mononuclear Cells of Cerebral Infarction Patients
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.4, pp.1-11
(Wonkwang Univ.)
Ji-Young,
S.
, &
Key-sang,
L.
(2005). The Effects of Danchunwhangagam on LPS or DFX-induced Cytokine Production in Peripheral Mononuclear Cells of Cerebral Infarction Patients. Journal of Korean Medicine, 26(4), 1-11.
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Abstract
Objective: This study was to investigate the effect of Danchunwhangagam(DCWGG) extract on the production of proinflammatory cytokines in peripheral blood mononuclear cells (PBMCs) from Cerebral infarction(CI) patients. Methods: We examined how the inhibition rate of tumor necrosis factor (TNF)-α, interleukin(IL)-1α, IL-1β, IL-6, and IL-8 productions in DCWGG pretreatment PBMCs culture supernatant in the lipopolysaccaride(LPS)- or desferrioxamine(DFX)-treated cells compared to unstimulated cells. Results: DCWGG inhibited the productions of TNF-α, IL-1α, IL-1β, IL-6, and IL-8 induced by LPS in a dose-dependent manner. Conclusion: DCWGG might have regulatory effects on LPS or DFX-induced cytokine production, which might explain its beneficial effect in the treatment of CI.
- keywords
- Danchunwhangagam, Cerebral Infarction, Cytokine
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