- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Log In/Sign Up
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Effect of Acupuncture on 6-Hydroxydopamine-induced Nigrostriatal Dopaminergic Neuronal Cell Death in Rats
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.4, pp.98-107
(Kyung-Won University)
(Kyung-Won University)
Yeung-Kee,
K.
, Yun-Kyung,
S.
, &
Hyung-Ho,
L.
(2005). Effect of Acupuncture on 6-Hydroxydopamine-induced Nigrostriatal Dopaminergic Neuronal Cell Death in Rats. Journal of Korean Medicine, 26(4), 98-107.
- Downloaded
- Viewed
Abstract
Objectives : Acupuncture treatment has been clinically used for functional recovery in Parkinson's disease. In the present study, we investigated the effect of acupuncture at Zusanli (ST36) on nigrostriatal dopaminergic neuronal cell death in rats. Methods : A Parkinson's disease model was induced by the unilateral injection of 6-hydroxydopamine (6-OHDA) into the striatum. Acupuncture treatment was performed at Zusanli (ST36) and at the hip, as a non-acupoint, once a day for 14 days. Two weeks after 6-OHDA injection, an apomorphine-induced rotational behavior test showed significant rotational asymmetry in rats with Parkinson's disease. Immunostaining for tyrosine hydroxylase demonstrated a dopaminergic neuronal loss in the substantia nigra and dopaminergic fiber loss in the striatum. Results : Acupuncture at the ST36 acupoint significantly inhibited rotational asymmetry in rats with Parkinson's disease, and also protected against 6-OHDA-induced nigrostriatal dopaminergic neuronal loss. These effects of acupuncture were not observed for non-acupoint acupuncture. Conclusions : The present study shows that acupuncture treatment, especially at the ST36 acupoint, can be used as a useful strategy for the treatment of Parkinson's disease.
- keywords
- Paeonia radix, Parkinson’ s disease, 1-Methyl-4-phenylpyridine, Apoptosis
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- The Effects of Danchunwhangagam on LPS or DFX-induced Cytokine Production in Peripheral Mononuclear Cells of Cerebral Infarction Patients
- Armeniacae Semen Extract Induces Apoptosis in Mouse N2a Neuroblastoma Cells
- Changes of Serum VEGF and b-FGF in 26 Patients with Breast Cancer after Treatment with Hang-Am-Dan (HAD), an Antiangiogenic Botanical Prescription
- Effects of Morindae Officinalis Radix on the Spermatogenesis and Antioxidant Activities in the SD Rat
- Efficacy of Oral Korean Red-ginseng on sCRP and Soreness after Muscle Damage
- Effects of Ampelopsis Radix Extracts on Tumor Immunity
- Effect of Baekyeum on Intestinal Motility
- The Ergogenic Effects of Red Ginseng and Paeonia radix Mixtures
- The Protective Effect of Paeoniae Radix Extract against 1-methyl-4- Phenylpyridium-induced Apoptosis on SK-N-MC Neuroblastoma Cells
- Neuroprotective Effect of Ginseng radix on ICH - induced Rats
- Effect of Acupuncture on 6-Hydroxydopamine-induced Nigrostriatal Dopaminergic Neuronal Cell Death in Rats
- Amygdalin Extract from Armeniacae semen Induces Apoptosis in Human COLO 201 Colon Cancer Cells
- The Clinical Effects of Ahnjeonbaekho-tang (AJBHT) on Graves’ Disease : A Prospective Clinical Study
- Amygdalin Extract from Armeniacae Semen Induces Apoptosis through Bax-dependent Caspase-3 Activation in Human Cervical Cancer Cell Line ME-180
- Clinical Study on the Effect of Exterior Vascular Laser Irradiation Therapy by Live Blood Analysis
- Harpagophytum Procumbens Suppresses Lipopolysaccharide Induced Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells
- Interpretation of the Five Viscera’s Ascending Kidney-Water and Descending Heart-Yang
- Case study of HBV-related Disasters in a High-risk Family
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.