- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
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Amygdalin Extract from Armeniacae Semen Induces Apoptosis through Bax-dependent Caspase-3 Activation in Human Cervical Cancer Cell Line ME-180
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.4, pp.130-142
(Kyung-Won University)
(Kyung-Won University)
(Kyungwon University)
(Kyung-Won University)
(Kyung-Won University)
(Kyungwon University)
(Kyung-Won University)
Seung-Peom,
C.
, Yun-Kyung,
S.
, Kyung-Jun,
K.
, &
Hyung-Ho,
L.
(2005). Amygdalin Extract from Armeniacae Semen Induces Apoptosis through Bax-dependent Caspase-3 Activation in Human Cervical Cancer Cell Line ME-180. Journal of Korean Medicine, 26(4), 130-142.
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Abstract
Objectives : Amygdalin is known to be a natural compound which has antitussive and anticancer activities. Amygdalin is abundant in the seeds of bitter almond and apricots of the Prunus genus, and other rosaceous plants. We investigated whether amygdalin induces apoptosis. Materials and Methods : 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)assay, terminal deoxynuclotidyl transferase (TdT)-mediated dUTP nick end-labeling (TUNEL) assay, 4,6-diamidino-2-phenylindole (DAPI) staining, flow cytometric analysis, DNA fragmentation assay, western blot, and caspase-3 enzyme assay were performed on ME-180 cervical cancer cells treated with amygdalin. Results : Through morphological and biochemical analyses, it was demonstrated that ME-180 cells treated with amygdalin exhibit several apoptotic features. It was shown that amygdalin induces increases in levels of Bax and caspase-3 and a decrease in Bcl-2 expression. Conclusions : These results suggest the possibility that amygdalin exerts an anti-tumor effect on human cervical cancer.
- keywords
- Amygdalin, Cervical cancer, Apoptosis, Chemotherapy
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