- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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The Protective Effect of Paeoniae Radix Extract against 1-methyl-4- Phenylpyridium-induced Apoptosis on SK-N-MC Neuroblastoma Cells
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.4, pp.74-86
(College of Oriental Medicine, Kyungwon University)
(Kyung-Won University)
(Kyung-Won University)
Ki-heon,
C.
, Yun-kyung,
S.
, &
Hyung-Ho,
L.
(2005). The Protective Effect of Paeoniae Radix Extract against 1-methyl-4- Phenylpyridium-induced Apoptosis on SK-N-MC Neuroblastoma Cells. Journal of Korean Medicine, 26(4), 74-86.
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Abstract
Background : There are increasing neuro-degenerative disorders with aging. Paeoniae Radix(PR) possesses various pharmacological effects such as sedative, analgesic, anti-inflammatory, anti-stress and neuro-protective actions. Also antiaging and anti-cancer effects of PR were reported. Our purpose was to investigate whether PR is useful on the treatment of Parkinson’s disease, one of the neuro-degenerative disorders. Objective : We investigated whether Paeonia Radix possesses a protective effect against 1-methyl-4- phenylpyridine(MPP+)-induced cytotoxicity in neuronal cells. Methods : 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay, flow cytometry, DNA fragmentation assay, reverse transcription-polymerase chain reaction(RT-PCR), and Western blotting were performed on SK-N-MC neuroblastoma cells. Results : Cells treated with MPP+ exhibited several apoptotic features, while cells pre-treated with Paeonia Radix prior to MPP+ exposure showed s decrease in the occurrence of apoptotic features. Conclusions : These results suggest that Paeonia Radix may exert a protective effect against MPP+-induced apoptosis in SK-N-MC neuroblastoma cells.
- keywords
- Paeonia radix, Parkinson’ s disease, 1-Methyl-4-phenylpyridine, Apoptosis
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