- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Harpagophytum Procumbens Suppresses Lipopolysaccharide Induced Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.4, pp.152-161
(Kyung-Won University)
(Kyung-Won University)
Hyun-Chol,
C.
, Yun-Kyung,
S.
, &
Hyung-Ho,
L.
(2005). Harpagophytum Procumbens Suppresses Lipopolysaccharide Induced Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells. Journal of Korean Medicine, 26(4), 152-161.
- Downloaded
- Viewed
Abstract
The excessive release of proinflammatory products by activated microglia causes neurotoxicity, and this has been implicated in the pathogenesis of neurodegenerative diseases. Harpagophytum procumbens (Pedaliaceae) has been widely used for the treatment of pain and arthritis in the clinical field. In this study, we investigated the effect of Harpagophytum procumbens against lipopolysaccharide-induced inflammation. From the present results, the aqueous extract of Harpagophytum procumbens was shown to suppress prostaglandin-E2 synthesis and nitric oxide production by inhibiting the lipopolysaccharide-stimulated enhancement of cyclooxygenase-2 and inducible nitric oxide synthase expressions in mouse BV2 microglial cells. These results suggest that Harpagophytum procumbens may offer a valuable means of therapy for the treatment of brain inflammatory diseases by attenuating lipopolysaccharide-induced prostaglandin-E2 synthesis and nitric oxide production
- keywords
- Harpagophytum procumbens, Lipopolysaccharide, Prostaglandin-E2, Nitric oxide
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- The Effects of Danchunwhangagam on LPS or DFX-induced Cytokine Production in Peripheral Mononuclear Cells of Cerebral Infarction Patients
- Armeniacae Semen Extract Induces Apoptosis in Mouse N2a Neuroblastoma Cells
- Changes of Serum VEGF and b-FGF in 26 Patients with Breast Cancer after Treatment with Hang-Am-Dan (HAD), an Antiangiogenic Botanical Prescription
- Effects of Morindae Officinalis Radix on the Spermatogenesis and Antioxidant Activities in the SD Rat
- Efficacy of Oral Korean Red-ginseng on sCRP and Soreness after Muscle Damage
- Effects of Ampelopsis Radix Extracts on Tumor Immunity
- Effect of Baekyeum on Intestinal Motility
- The Ergogenic Effects of Red Ginseng and Paeonia radix Mixtures
- The Protective Effect of Paeoniae Radix Extract against 1-methyl-4- Phenylpyridium-induced Apoptosis on SK-N-MC Neuroblastoma Cells
- Neuroprotective Effect of Ginseng radix on ICH - induced Rats
- Effect of Acupuncture on 6-Hydroxydopamine-induced Nigrostriatal Dopaminergic Neuronal Cell Death in Rats
- Amygdalin Extract from Armeniacae semen Induces Apoptosis in Human COLO 201 Colon Cancer Cells
- The Clinical Effects of Ahnjeonbaekho-tang (AJBHT) on Graves’ Disease : A Prospective Clinical Study
- Amygdalin Extract from Armeniacae Semen Induces Apoptosis through Bax-dependent Caspase-3 Activation in Human Cervical Cancer Cell Line ME-180
- Clinical Study on the Effect of Exterior Vascular Laser Irradiation Therapy by Live Blood Analysis
- Harpagophytum Procumbens Suppresses Lipopolysaccharide Induced Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells
- Interpretation of the Five Viscera’s Ascending Kidney-Water and Descending Heart-Yang
- Case study of HBV-related Disasters in a High-risk Family
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.