- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Neuroprotective Effect of Ginseng radix on ICH - induced Rats
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.4, pp.87-97
(College of Oriental Medicine, Kyungwon University)
(Kyung-Won University)
(Kyung-Won University)
(Kyung-Won University)
(Kyung-Won University)
Kwan-Ho,
J.
, Yun-Kyung,
S.
, &
Hyung-Ho,
L.
(2005). Neuroprotective Effect of Ginseng radix on ICH - induced Rats. Journal of Korean Medicine, 26(4), 87-97.
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Abstract
Backgrounds : Intracerebral hemorrhage is one of the most devastating types of stroke. Ginseng radix, the root of Panax Ginseng, C. A. MEYER (Araliaceae), is one of the most famous medicinal herbs with various therapeutic applications. Objectives : In the present study, the effect of aqueous extract of Ginseng radix on intracerebral hemorrhage-induced neuronal cell death in rats was investigated. Materials and Methods : Step-down avoidance task, Nissl staining, immunohistochemistry for caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay were used for this study. Results : The present results show that hemorrhage-induced lesion volume and apoptotic neuronal cell death in the striatum were significantly suppressed by treatment with Ginseng radix, resulting in enhancement of short-term memory. Conclusions : We have shown that Ginseng radix has a neuroprotective effect on stroke, and aids the recovery from central nervous system sequelae following stroke.
- keywords
- Intrastriatal hemorrhage, Ginseng radix, short-term memory, apoptotic neuronal cell death
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