- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Effects of Ampelopsis Radix Extracts on Tumor Immunity
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.4, pp.46-55
(Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(Daejeon University)
(East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(Korean Institute of Oriental Medicine)
(East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(Daejeon University)
(East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
(Korean Institute of Oriental Medicine)
(East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
Seung-Man,
P.
, Jung-Hyo,
C.
, Chang-Gue,
S.
, Jang-Wo,
S.
, Yeon-Weol,
L.
, Hwa-Seung,
Y.
, Nam-heon,
L.
, Dam-hee,
Y.
, Sang-Woo,
A.
, &
Chong-Kwan,
C.
(2005). Effects of Ampelopsis Radix Extracts on Tumor Immunity. Journal of Korean Medicine, 26(4), 46-55.
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Abstract
Objectives : This experimental study was carried out to evaluate the immune modulating and anti-tumor activity of Ampelopsis Radix extracts (ARE). Materials and Methods : To elucidate the effects of ARE on the macrophage and NK cell activity, we analyzed NO production, NK cytotoxicity and gene expressions of cytokine related with macrophage and NK cell activity. Results : ARE activated and promoted macrophages to product NO in part. And, ARE has significant properties to activate macrophages and NK cells by promoting related cytokines like IL-1, IL-12, IFN-γ, iNOS and TNF-αgene expressions. We also observed that ARE promoted protein expression of IFN-γ, and TNF-αin mice splenocytes. Conclusions : ARE is an effective herbal drug for immune modulating and anti-cancer by promoting activity of macrophages and NK cells.
- keywords
- Immune modulating, anti-cancer, macrophages, NK cell
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