- P-ISSN 1010-0695
- E-ISSN 2288-3339
- P-ISSN1010-0695
- E-ISSN2288-3339
논문 상세
Home > 논문 상세
Effect of Acupuncture on 6-Hydroxydopamine-induced Nigrostriatal Dopaminergic Neuronal Cell Death in Rats
대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2005, v.26 no.4, pp.98-107
(경원대학교)
(Kyung-Won University)
(Kyung-Won University)
(Kyung-Won University)
(Kyung-Won University)
Yeung-Kee,
K.
, Yun-Kyung,
S.
, &
Hyung-Ho,
L.
(2005). . , 26(4), 98-107.
- 0다운로드 수
- 241조회수
Abstract
Objectives : Acupuncture treatment has been clinically used for functional recovery in Parkinson's disease. In the present study, we investigated the effect of acupuncture at Zusanli (ST36) on nigrostriatal dopaminergic neuronal cell death in rats. Methods : A Parkinson's disease model was induced by the unilateral injection of 6-hydroxydopamine (6-OHDA) into the striatum. Acupuncture treatment was performed at Zusanli (ST36) and at the hip, as a non-acupoint, once a day for 14 days. Two weeks after 6-OHDA injection, an apomorphine-induced rotational behavior test showed significant rotational asymmetry in rats with Parkinson's disease. Immunostaining for tyrosine hydroxylase demonstrated a dopaminergic neuronal loss in the substantia nigra and dopaminergic fiber loss in the striatum. Results : Acupuncture at the ST36 acupoint significantly inhibited rotational asymmetry in rats with Parkinson's disease, and also protected against 6-OHDA-induced nigrostriatal dopaminergic neuronal loss. These effects of acupuncture were not observed for non-acupoint acupuncture. Conclusions : The present study shows that acupuncture treatment, especially at the ST36 acupoint, can be used as a useful strategy for the treatment of Parkinson's disease.
- keywords
- Paeonia radix, Parkinson’ s disease, 1-Methyl-4-phenylpyridine, Apoptosis
- 0다운로드 수
- 241조회수
- 0KCI 피인용수
- 0WOS 피인용수
권호 내 다른 논문
- The Effects of Danchunwhangagam on LPS or DFX-induced Cytokine Production in Peripheral Mononuclear Cells of Cerebral Infarction Patients
- Armeniacae Semen Extract Induces Apoptosis in Mouse N2a Neuroblastoma Cells
- Changes of Serum VEGF and b-FGF in 26 Patients with Breast Cancer after Treatment with Hang-Am-Dan (HAD), an Antiangiogenic Botanical Prescription
- Effects of Morindae Officinalis Radix on the Spermatogenesis and Antioxidant Activities in the SD Rat
- Efficacy of Oral Korean Red-ginseng on sCRP and Soreness after Muscle Damage
- Effects of Ampelopsis Radix Extracts on Tumor Immunity
- Effect of Baekyeum on Intestinal Motility
- The Ergogenic Effects of Red Ginseng and Paeonia radix Mixtures
- The Protective Effect of Paeoniae Radix Extract against 1-methyl-4- Phenylpyridium-induced Apoptosis on SK-N-MC Neuroblastoma Cells
- Neuroprotective Effect of Ginseng radix on ICH - induced Rats
- Effect of Acupuncture on 6-Hydroxydopamine-induced Nigrostriatal Dopaminergic Neuronal Cell Death in Rats
- Amygdalin Extract from Armeniacae semen Induces Apoptosis in Human COLO 201 Colon Cancer Cells
- The Clinical Effects of Ahnjeonbaekho-tang (AJBHT) on Graves’ Disease : A Prospective Clinical Study
- Amygdalin Extract from Armeniacae Semen Induces Apoptosis through Bax-dependent Caspase-3 Activation in Human Cervical Cancer Cell Line ME-180
- Clinical Study on the Effect of Exterior Vascular Laser Irradiation Therapy by Live Blood Analysis
- Harpagophytum Procumbens Suppresses Lipopolysaccharide Induced Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells
- Interpretation of the Five Viscera’s Ascending Kidney-Water and Descending Heart-Yang
- Case study of HBV-related Disasters in a High-risk Family
- more
추천 논문
- A Case Report of a Patient with Normal tension glaucoma
- Medical Volunteering Experiences of Korean Medicine Students: Developing an HSS-Based Pre-Education Program
- Exploring Future Directions for Korean Medical Infertility Programs: Insights from In-Depth Interviews with Female Participants
- Integrating Generative AI into Clinical Practice Education: Enhancing Personalized Medicine Delivery Skills for Korean Medicine Students
- A Statistical Study of 36 cases on the Effect of Korean Medicine Treatment including TBT on Facial Asymmetry Correction
- The Effects of Danchunwhangagam on LPS or DFX-induced Cytokine Production in Peripheral Mononuclear Cells of Cerebral Infarction Patients
- Effect of Acupuncture on 6-Hydroxydopamine-induced Nigrostriatal Dopaminergic Neuronal Cell Death in Rats
- Case study of HBV-related Disasters in a High-risk Family
- The Ergogenic Effects of Red Ginseng and Paeonia radix Mixtures
- Interpretation of the Five Viscera’s Ascending Kidney-Water and Descending Heart-Yang
학술지 홈페이지 이용 환경은 크롬 브라우저 사용을 권장합니다.