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E-ISSN : 2733-4538
Impairment of inhibitory mechanisms in patients with Alzheimer's disease (AD) remains controversial. Recent reviews regarding inhibitory functioning in AD have suggested that automatic inhibitory processes are intact while controlled inhibitory processes are impaired in patients with AD. The author examined the inhibition of return(i.e., automatically evoked inhibition; IOR) and flanker task(i.e., intentionally evoked inhibition) in a group of 15 patients with mild AD and 17 age-matched healthy controls (HC). Patients with mild AD exhibited significant IOR effects. A planned comparison revealed that unlike the HC, who exhibited significant IOR effects at all stimulus onset asynchrony(SOA), patients with mild AD exhibited significant IOR effects only at 800ms SOA. Further, the HC and patients with mild AD demonstrated significant inhibition with respect to the flanker task. These findings suggested that in the early stages of AD, automatic inhibitory processes may be intact whereas controlled inhibitory processes may be impaired. Finally, limitations of this study and suggestions for future studies were discussed.
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