- P-ISSN 1225-0163
- E-ISSN 2288-8985
- 권한신청
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
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국내 합성피혁제조업 근로자에 대한 디메틸포름아미드의 공기중농도와 생물학적 노출지표간의 상관성 평가
Assessment of correlation between markers of ambient monitoring and biological monitoring of dimethylformamide for workers in synthetic leather manufacturing factories in Korea
분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2013, v.26 no.5, pp.315-325
https://doi.org/10.5806/AST.2013.26.5.315
(한국산업안전보건공단)
(한국산업안전보건공단)
(한림대학교병원)
(한국산업안전보건공단)
(한국산업안전보건공단)
(한림대학교병원)
(한국산업안전보건공단)
황양인,
이미영,
정윤경,
&
김은아.
(2013). 국내 합성피혁제조업 근로자에 대한 디메틸포름아미드의 공기중농도와 생물학적 노출지표간의 상관성 평가. 분석과학, 26(5), 315-325, https://doi.org/10.5806/AST.2013.26.5.315
- 다운로드 수
- 조회수
Abstract
The possibility of acute hepatotoxicity caused by dimethylformamide (DMF) requires regular monitoring of the workers who are using DMF to prevent the occupational disease. The authors performed ambient and biological monitoring of workers involved in synthetic leather manufacturing processes using DMF to assess the correlation between the markers of ambient and biological monitoring of DMF. The authors monitored 142 workers occupationally exposed to DMF from 19 workshops in the synthetic leather and ink manufacturing industries located in northern region of Gyeonggi-do. The subjects answered questionnaire on work procedure and use of personal protective equipment to be classified by exposure type. DMF in air samples collected using personal air samplers,diffusive and active sampler, was analysed using gas chromatograph-flame ionization detector (GC-FID) with DBFFAP column (length 30 m, i.d. 0.25 mm, film thickness 0.25 μm). Urinary N-methylformamide (NMF) was analysed using gas chromatograph-mass selective detector (GC-MSD) at selected ion monitoring (SIM) mode with DB-624 column (length 60 m, i.d. 0.25 mm, film thickness 1.40 μm). Geometric mean (GM) and geometric standard deviation (GSD) of the ambient DMF was 6.85 ± 3.43 ppm, and GM and GSD of urinary NMF was 42.3 ± 2.7mg/L. The ratio of subjects with DMF level over 10 ppm was 44%, and those with urinary NMF over 15 mg/L was 87%. NMF in urine adjusted by DMF in air was 4.61 ± 2.57 mg/L/ppm and 9.50 ± 2.41 mg/L/ppm,respectively, with or without respirator. There was seasonal differences of NMF in urine adjusted by DMF in air,7.63 ± 2.74 mg/L/ppm in summer and 4.53 ± 2.29 mg/L/ppm in winter. The urinary NMF concentration which corresponds to 10 ppm of ambient DMF was 52.7 mg/L (r=0.650, n=128). Considering the difference of the route of exposure which resulted from the compliance of wearing personal protective equipment, the estimated contribution of respiratory and dermal exposure route for DMF was 48.5% vs. 51.5%.
- keywords
- Dimethylformamide (DMF), N-Methylformamide (NMF), biological monitoring, occupational exposure, dermal exposure, personal protective equipment
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