- P-ISSN 1225-0163
- E-ISSN 2288-8985
- 권한신청
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
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Determination of the quantity of tolperisone hydrochloride in tablets by high performance liquid chromatography
분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2017, v.30 no.1, pp.32-38
https://doi.org/10.5806/AST.2017.30.1.32
(강원대학교)
(강원대학교)
(강원대학교)
(강원대학교)
(강원대학교)
(충남대학교)
(대구가톨릭대학교)
(경북대학교)
(The Society of Korean Official Compendium for Publ)
(강원대학교)
(강원대학교)
(강원대학교)
(강원대학교)
(충남대학교)
(대구가톨릭대학교)
(경북대학교)
(The Society of Korean Official Compendium for Publ)
Quoc,
K.
T.
,
김경호,
Xuan,
L.
M.
,
김대현,
김전경,
강종성,
우미희,
나동희,
&
전인구.
(2017). . 분석과학, 30(1), 32-38, https://doi.org/10.5806/AST.2017.30.1.32
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Abstract
In attempt to contribute in official monographs of Korean Pharmacopoeia, an HPLC method was developed and fully validated for the determination of tolperisone hydrochloride in tablets which have never been published in other forgein Pharmacopoeia. Analysis was carried out in an ODS column (250 × 4.6 mm I.D., 5 μm) with common solvents include acetonitrile and ammonium hydrophosphate buffer as mobile phase. The assay was validated according to International Conference on Harmonization (ICH) guidelines. The method has good linearity in the range of 5 – 200 μg/mL tolperisone. Intra-day precision varied between 0.04 and 0.10 %. Relative standard deviations of inter-day precision ranged between 0.43 and 1.24 % for peak area. The percentage recovery of the tolperisone ranged between 99.8 and 101.2 % in material. Recoveries in tablets were ranged between 98.7 and 100.8 %, thus confirmed the suitability of method for estimation of tolperisone hydrochloride in tablet dosage form.
- keywords
- tolperisone, HPLC, assay, validation, tablet dosage form
참고문헌
1
1. Martindale, The Extra Pharmacopoeia 30th edition, A. G. Lipman, The Pharmaceutical Press, London, 1211(1993).
2
2. The Japanese Pharmacopoeia, 17th Edition, The Ministry of Health, Labour and Welfare, Japan (2016).
3
3. The Korean Pharmacopoeia, 11th Edition, Ministry of Food and Drug Safety, Republic of Korea (2014).
4
4. N. Youngvises, B. Liawruangrath, and S. Liawruangrath, J. Pharm. Biomed. Anal., 31, 629-638 (2003).
5
5. S. Liawruangrath, B. Liawruangrath, and P. Pibool, J. Pharm. Biomed. Anal., 26, 865-872 (2001).
6
6. N. R. Rao and S. S. Raju, Chirality, 25(10), 622-627(2013).
7
7. I. C. Nimila, P. Balan, N. Chiranjeevi, and V. V. V. M. Kumar, Int. J. Pharm. Pharm. Sci., 4(5), 84-85 (2012).
8
8. N. Miura, T. Saito, T. Taira, T. Yamagiwa, S. Morita, and S. Inokuchi, J. AOAC Int., 97(6), 1546-1551 (2014).
9
9. T. V. R. Raju, R. K. Seshadri, S. Arutla, T. S. S. J. Mohan, I. M. Rao, and S. R. Nittala, Sci. Pharm., 81, 123-138 (2013).
10
10. J. W. Bea, Y. S. Park, U. D. Sohn, C. S. Myung, B. K. Ryu, C. G. Jang, and S. Y. Lee, Arch. Pharm. Res., 29(4), 399-342 (2006).
11
11. C. I. Choi, J. I. Park, H. I. Lee, Y. J. Lee, C. G. Jang, J.W. Bea, and S. Y. Lee, J. Chromatogr. B, 911, 59-63(2012).
12
12. Y. Owada, M. Takahashi, S. Iwasa, H. Ichiba, K. Sadamoto, and T. Fukushima, Biomed. Chromatogr., 28, 102-105(2014).
13
13. M. Murali and P. V. V. Satyanarayana, Der Pharma. Chemica, 3(5), 13-19 (2011).
14
14. ICH Guideline. Q2(R1): validation of Analytical Procedures: Text and Methodology Q2(R1) in ICH Harmonised Tripartite Guideline (2005).
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