- P-ISSN 1225-0163
- E-ISSN 2288-8985
- 권한신청
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
논문 상세
Home > 논문 상세
Qualitative and quantitative determination of oleanolic acid in a scalp tonic products by HPLC using response surface methodology for extraction optimization
분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2019, v.32 no.2, pp.48-55
https://doi.org/10.5806/AST.2019.32.2.48
(College of Pharmacy, Chungnam National University)
(College of Pharmacy, Chungnam National University)
(School of Pharmacy, Yantai University)
(College of Pharmacy, Chungnam National University)
(Department of Food Science & Technology, Dong-Eui University)
(College of Pharmacy, Chungnam National University)
(College of Pharmacy, Chungnam National University)
(School of Pharmacy, Yantai University)
(College of Pharmacy, Chungnam National University)
(Department of Food Science & Technology, Dong-Eui University)
(College of Pharmacy, Chungnam National University)
Lin,
X.
C.
,
조종운,
Yan,
Z.
,
Jong-Seong,
K.
,
Kyung,
T.
K.
,
&
Sang-Hun,
J.
(2019). . 분석과학, 32(2), 48-55, https://doi.org/10.5806/AST.2019.32.2.48
- 다운로드 수
- 조회수
Abstract
The simple and effective analytical method for the quality control of a novel scalp tonic formulation has been developed and optimized in terms of HPLC conditions and sample preparation method, meanwhile, the optimization of preparation condition was using response surface methodology (RSM) based on central composite design (CCD). Oleanolic acid was selected as marker compound because of its bioactivities for alopecia therapy. The developed analytical method and extraction condition were successfully qualified. Coefficient of determination (r2) for the calibration was 0.9997 with a line passing through the origin point in the range of 0.1-100 mg/mL. The limit of detection (LOD) and the limit of quantitation (LOQ) were 17.5 ng/mL and 55.0 ng/mL, respectively. The intra-day and inter-day precision of the method were 0.5-1.4 % and 0.7-1.8 % in relative standard deviation, respectively, while those accuracy were 99.5-100.9 % and 100.0- 102.2 %, respectively. The repeatability of oleanolic acid in samples ranged of 0.3-1.9 % based on peak area and 0.3-0.7 % for retention time. Recoveries from samples were 95.0-99.4 % with lower than 1.8 % in relative standard deviation. Overall, the developed analytical method will be used for quality control of this commercial scalp tonic products successfully.
- keywords
- Scalp tonic, oleanolic acid, response surface methodology (RSM), quality control, HPLC
참고문헌
1
1. L. H. Su, L. S. Chen, and H. H. Chen, J. Am. Acad. Dermatol., 69(2), 69-77 (2013).
2
2. R. C. Gathers and M. G. Mahan, J. Clin. Aesthet. Dermatol., 7, 26-29 (2014).
3
3. M. Alfonso, H. Richter-Appelt, A. Tosti, M. S. Viera, and M. Garcia, Curr. Med. Res.Oper., 21, 1829-1836 (2005).
4
4. S. J. Yun, J.-W. Lee, H.-J. Yoon, S. S. Lee, S.-Y. Kim, J.-B. Lee, S.-C. Lee, Y.-H. Won, and S.-J. Kim, J. Dermatol., 34, 451-455 (2007).
5
5. P. Mirmirani, Maturitas, 74(2), 119-122 (2013).
6
6. J. R. Barrett, Environ. Health. Perspect., 113, A24 (2005).
7
7. Ministry of Food and Drug Safety, Korean Herbal Pharmacopeia. Part III, pp. 156-157, Republic of Korea (2015).
8
8. Y. Ling, Z. Lin, W. Zha, T. Lian, and S. You, Phytochem. Anal., 27, 174-183(2016).
9
9. L. Cheng, M. Zhang, P. Zhang, Z. Song, Z. Ma, and H. Qu, Rapid Commun. Mass. Spectrom., 22, 3783-3790(2008).
10
10. H. Xu, X. Shi, X. Ji, Y. Du, H. Zhu, and L. Zhang, J. Sep. Sci., 34, 308-316 (2011).
11
11. H.-J Xu, X.-W. Shi, Y.-F. Du, H. Zhu, and L.-T. Zhang, Food Chem., 135, 251-258 (2012).
12
12. S. C. Bang, Y. Kim, J. H. Lee, and B. Ahn, J. Nat. Prod., 68, 268-272 (2005).
13
13. X. Ding, ‘Chemical component study of China medicine-Baitouweng’, Master thesis, Soochow University, Suzhou, Taipei (2010).
14
14. J. Li, W.-J. Guo, and Q.-Y. Yang, World J. Gastroenterol., 8, 493-495 (2002).
15
15. S.-J. Tsai and M.-C Yin, J. Food Sci., 73, H174-H178(2008).
16
16. X. Wang, H. Bai, X. Zhang, J. Liu, P. Cao, N. Liao, W. Zhang, Z. Wang, and C. Hai, Carcinogen., 34, 1323-1330 (2013).
17
17. J. Pollier and A. Goossens, Phytochem., 77, 10-15 (2012).
18
18. K. I. Wolska, A. M. Grudniak, B. Fiecek, A. Kraczkiewicz-Dowjat, and A. Kurek, Cent. Eur. J. Biol., 5, 543-553(2010).
19
19. J. A. Jesus, J. H. G. Lago, M. D. Laurenti, E. S. Yamamoto, and L. F. D. Passero, Evidence-Based Complement. Altern. Med., 2015, ID.620472 (2015).
20
20. M. Suzuki, Y. Ninagawa, K. Hosokawa, K. Matsunaga, and R. Hayakawa, Skin, 31(4), (1989).
21
21. K. Lintner, C. Maschamberlin, Patent, US20060067905(2006).
22
22. T. Cabanas, Carles, Foyaca Ferrer, Monica, “Anti-hair loss lotion”, Patent, WO2017021247, 2017.
23
23. S. Li, Q. Han, C. Qiao, J. Song, C. L. Cheng, and H. Xu, Chin. Med., 3, Doi: 10.1186/1749-8546-3-7, 2008.
24
24. Q. Chen, Y. Zhang, W. Zhang, and Z. Chen, Biomed. Chromatogr., 25),1381-1388 (2011).
25
25. L. Zhao, W. Li, Y. Li, H. Xu, L. Lv, X. Wang, Y. Chai, and G. Zhang, J. Chromatogr. Sci., 53, 1185-1192 (2015).
26
26. J. Peragón, E. E. Rufino-Palomares, I. Muñoz-Espada, F. J. Reyes-Zurita, and J. A. Lupiáñez, Int. J. Mol. Sci., 16, 21681-21694 (2015).
27
27. V. Aeri, M. I. Khan. and S. Alam, Int. J. Pharm. Pharmaceut. Sci., 2, 74-78 (2010).
28
28. The State Commission of Pharmacopoeia, Pharmacopeia of People’s Republic of China, The Medicine Science and Technology Press of China, Beijing, PRC, Part I, 163, People’s Republic of China (2015).
29
29. Ministry of Food and Drug Safety, Korean Pharmacopoeia, Part II, p.1851, Republic of Korea (2015).
권호 내 다른 논문
- Development and validation of an LC-MS/MS method for the simultaneous analysis of 26 anti-diabetic drugs in adulterated dietary supplements and its application to a forensic sample
- Qualitative and quantitative determination of oleanolic acid in a scalp tonic products by HPLC using response surface methodology for extraction optimization
- Rapid determination and quantification of hair-growth compounds in adulterated products by ultra HPLC coupled to quadrupole-orbitrap MS
- Identification of pollutant sources using water quality and stable isotope ratios of inflow tributaries in the lower reaches of the Han-River
- more
추천 논문
학술지 홈페이지 이용 환경은 크롬 브라우저 사용을 권장합니다.