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- E-ISSN 2288-8985
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Rapid determination and quantification of hair-growth compounds in adulterated products by ultra HPLC coupled to quadrupole-orbitrap MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2019, v.32 no.2, pp.56-64
https://doi.org/10.5806/AST.2019.32.2.56
(National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
(National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
(National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
(National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
(National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
(College of Pharmacy, Kangwon National University)
(National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
(National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
(National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
(National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
(National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
(College of Pharmacy, Kangwon National University)
(National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Ji,
H.
L.
, Han,
N.
P.
, Gihaeng,
K.
, Nam,
S.
K.
, Seongsoo,
P.
, Jongkook,
L.
, &
Hoil,
K.
(2019). Rapid determination and quantification of hair-growth compounds in adulterated products by ultra HPLC coupled to quadrupole-orbitrap MS. Analytical Science and Technology, 32(2), 56-64, https://doi.org/10.5806/AST.2019.32.2.56
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Abstract
Recently, a number of adulterated products, which are advertised as hair-growth enhancer have been emerged among those who suffer hair loss disease. For continuous control of illegal products, in this study, a rapid and sensitive method for simultaneous screening of 12 compounds that enhance hair-growth was established to protect public health by ultrahigh-performance liquid chromatography coupled to quadrupoleorbitrap mass spectrometry (UHPLC-Q-Orbitrap-MS). Fragmentation pathways of them were proposed based on MS2 spectral data obtained using the established method. In this analysis, the LODs and LOQs ranged from 0.05 to 50 ng/mL and from 0.17 to 167 ng/mL, respectively. The square of the linear correlation coefficient (R2) was determined as more than 0.995. The intra- and inter-assay accuracies were respective 88-112 % and 88-115 %. Their precision values were measured within 5 % (intra-day) and 10 % (inter-day). Mean recoveries of target compounds in adulterated products ranged from 84 to 115%. The relative standard deviation of stability was less than 12 % at 4 °C for 48 h. The method was employed to screen 14 dietary supplements advertised to be effective for the treatment of hair loss. Some of the products (~21 %) were proven to contain synthetic drugs that promote hair growth such as triaminodil, minoxidil, and finasteride.
- keywords
- hair loss, adulterants, UHPLC-Q-Orbitrap-MS, screening, validation, fragmentation pathway
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