• P-ISSN1225-0163
  • E-ISSN2288-8985
  • SCOPUS, ESCI, KCI

논문 상세

Home > 논문 상세
  • P-ISSN 1225-0163
  • E-ISSN 2288-8985

논문 상세

    Discrimination between steam processed and unprocessed Tubers of Gastrodia elata Blume by HPLC

    분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
    2019, v.32 no.6, pp.217-224
    https://doi.org/10.5806/AST.2019.32.6.217
    Bing Tian Zhao (College of Pharmacy, Catholic University of Daegu,School of Chemical and Material Engineering, Jiangnan University)
    Si Whan Song (ChemOn Inc., Gyeonggi Bio-Research Center)
    Duc Dat Le (College of Pharmacy, Catholic University of Daegu)
    Eunsook Ma (College of Pharmacy, Catholic University of Daegu)
    Jong-Keun Son (College of Pharmacy, Yeungnam University)
    Mi Hee Woo (College of Pharmacy, Catholic University of Daegu)
    • 72다운로드 수
    • 292조회수

    Abstract

    In this study, to evaluate the effectiveness and safety of oral therapy using Gastrodiae Rhizoma, a new HPLC-PDA analysis method was developed for the simultaneous quantitation of the three major components: (1) gastrodin, (2) gastrodigenin, and (3) p-hydroxybenzaldehyde, in steam processed and unprocessed tubers of Gastrodia elata Blume. The clear separation of the three components was achieved on a C18 column (250 × 4.6 mm, 5 μm) by gradient elution using water (including 0.1 % formic acid) and acetonitrile as the mobile phase. The flow rate was 1.0 mL/min, and the UV detector wavelength was set at 270 nm. The results demonstrate satisfactory linearity, recovery, precision, accuracy, stability, and robustness. The established HPLC-PDA method was applied to quantify three major compounds in 59 samples of G. elata Blume tubers. Finally, the steam processed and unprocessed tubers of G. elata Blume were successfully distinguished by pattern recognition analysis.

    keywords
    gastrodiae rhizoma, gastrodin, gastrodigenin, p-hydroxybenzaldehyde


    참고문헌

    1

    1. H. D. Zhan, H. Y. Zhou, X. L. Du, Y. P. Sui, W. H. Wang, L. Dai, F. Sui, H. R. Huo, and T. L. Jiang, J. Ethnopharmacol., 189, 361-385 (2016).

    2

    2. Q. Fan, C. Chen, Z. Huang, C. Zhang, P. Liang, and S. Zhao, Spectrochim. Acta A, 136, 1621-1625 (2015).

    3

    3. R. L. Bi, R. F. Sun, D. X. Li, and X. Y. Liu, J. West China Forestry Sci., 43, 116-118 (2014).

    4

    4. N. Wang, T. X. Wu, Y. Zhang, X. B. Xu, S. Tan, and H. W. Fu, Arch. Pharm. Res., 36, 314-321 (2013).

    5

    5. X. M. Huang, C. Qi, Y. Y. Zhu, and R. Shi, J. Zhaotong Univ., 39, 42-47 (2017).

    6

    6. Z. K. Liu, C. F. Ng, H. T. Shiu, H. L. Wong, C. W. Wong, K. K. Li, J. F. Zhang, P. K. Lam, W. S. Poon, C. B. S. Lau, P. C. Leung, and C. H. Ko, J. Ethnopharmacol., 196, 20-28 (2017).

    7

    7. Ministry of Health of the People's Republic of China, China Pharmacopoeia Chemical Industry Press, Beijing, 58-59 (2015).

    8

    8. Ministry of Food and Drug Safety, Korean Pharmacopoeia Part II, 11th edn. Shinil Books, Seoul, 104-105 (2016).

    9

    9. The Minister of Health, Labor and Welfare of Japan, The Japanese Pharmacopoeia. 17th ed. The Minister of Health, Labor and Welfare of Japan Press: Tokyo, 1855-1856 (2016).

    10

    10. R. L. Bi, F. N. Zhao, W. Guo, and X. Y. Liu, Yunnan Chem. Technol., 44, 35-38 (2017).

    11

    11. Y. Li, Z. W. Wang, D. H. Liu, H. L. Zhou, and X. Wang, Shandong Sci., 30, 7-12 (2017).

    12

    12. H. Y. Wong, B. Hu, P. K. So, C. O. Chan, D. K. W. Mok, G. Z. Xin, P. Li, and Z. P. Yao, Anal. Chim. Acta, 938, 90-97 (2016).

    13

    13. X. Zhang, Z. Ning, D. Ji, Y. Chen, C. Mao, and T. Lu, J. Sep. Sci., 38, 3815-3982 (2015).

    14

    14. J. Y. Kwon, N. Y. Kim, D. H. Lee, A. R. Han, J. W. Lee, E. K. Seo, J. H. Lee, and D. H. Lee, J. Pharmaceut. Biomed., 94, 132-138 (2014).

    15

    15. C. Tang, B. Wu, J. Wu, Z. Zhang, and B. Yu, Molecules, 23, E270 (2018).

    16

    16. Y. Li, Y. Zhang, Z. Zhang, Y. Hu, X. Hu, X. Cui, and Y. Xiong, Molecules, 24, E1521 (2019).

    17

    17. Y. Li, X. Q. Liu, S. S. Liu, D. H. Liu, X. Wang, and Z. M. Wang, Molecules, 24, E3159 (2019).

    18

    18. Y. H. Kim, and B. I. Seo, J. Jeahan Orient. Med. Acad., 10, 137-145 (2012).

    19

    19. J. Liang, P. Zhao, B. Li, W. T. He, F. W. Li , L. He, W. Z. Fu, and Q. He, J. China Trop. Med., 5, 1986-1988(2005).

    20

    20. Y. L. Lu, D. X. Liu, and F. C. Xiao, Yunnan J. Tradit. Chin. Med. & Mater. Medica., 31, 93 (2010).

    21

    21. Z. X. Lv, Z. H. Che, Y. Tang, J. Chen, C. P. Zhang, and Q. L. Liu, Clin. J. Chin. Med., 9, 44-45 (2017).

    22

    22. Y. F. Bai, H. Yin, H. P. Bi, Y. B. Zhuang, T. Liu, and Y. H. Ma, Metab. Eng., 35, 138-147 (2016).

    • 72다운로드 수
    • 292조회수
    • 0KCI 피인용수
    • 0WOS 피인용수

    추천 논문

    분석과학