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Simultaneous qualitative and quantitative analysis of morroniside and hederacoside D in extract mixture of Cornus officinalis and Stauntonia hexaphylla leaves to improve benign prostatic hyperplasia by HPLC-UV
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2020, v.33 no.5, pp.224-231
https://doi.org/10.5806/AST.2020.33.5.224
(College of Pharmacy, Chungnam National University)
(College of Pharmacy, Chungnam National University)
(College of Pharmacy, Chungnam National University / Institute of Marine Biochemistry (IMBC), Vietnam Academic of Science and Technology (VAST))
(College of Pharmacy, Chungnam National University)
(Chong Kun Dang Healthcare)
(College of Pharmacy, Chungnam National University)
(College of Pharmacy, Chungnam National University)
(College of Pharmacy, Chungnam National University)
(College of Pharmacy, Chungnam National University / Institute of Marine Biochemistry (IMBC), Vietnam Academic of Science and Technology (VAST))
(College of Pharmacy, Chungnam National University)
(Chong Kun Dang Healthcare)
(College of Pharmacy, Chungnam National University)
(College of Pharmacy, Chungnam National University)
Gao,
D.
, Chong,
W.
C.
, Le,
B.
V.
, Jin,
H.
K.
, Kyoung,
W.
C.
, Young,
H.
K.
, &
Jong-Seong,
K.
(2020). Simultaneous qualitative and quantitative analysis of morroniside and hederacoside D in extract mixture of Cornus officinalis and Stauntonia hexaphylla leaves to improve benign prostatic hyperplasia by HPLC-UV. Analytical Science and Technology, 33(5), 224-231, https://doi.org/10.5806/AST.2020.33.5.224
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Abstract
With the improvement in the standard of living and extension of life expectancy, the incidence of prostate diseases has increased yearly, thus becoming a serious disease affecting the health of men. The extract mixture of Cornus officinalis and Stauntonia hexaphylla leaves is a developed functional food formula to improve prostate health. This study developed a simultaneous analytical method of bioactive compounds for quantifying the mixture of Cornus officinalis and S. hexaphylla leaves using high-pressure liquid chromatography-ultraviolet (HPLC–UV). HPLC analytical condition was performed on a Hector C18 column with a mobile phase of 0.1 % formic acid in water (A) and 0.1 % formic acid in acetonitrile (B) under the following gradient conditions: 0-50 min, 12 %-40 % (B) at a flow rate of 1.0 mL/min. Meanwhile, this method was validated properly and successfully used to quantify the bioactive components of morroniside and hederacoside D in 20 sample batches and assess the quality of different ages and seasons of S. hexaphylla leaves. The result showed that the content of morroniside in the extract mixture of Cornus officinalis and S. hexaphylla leaves ranged from 1.38-1.62 mg/g, and the hederacoside D ranged from 28.42-32.02 mg/g, suggesting that this novel analytical method will be suitable for the quality control of the extract mixture to improve benign prostatic hyperplasia.
- keywords
- benign prostatic hyperplasia, HPLC-UV, cornus officinalis, stauntonia hexaphylla, LC-ESI-MS/MS
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