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- E-ISSN 2288-8985
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Spectrofluorometric quantification of Clozapine in pharmaceutical formulations and human plasma
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2022, v.35 no.1, pp.24-31
https://doi.org/10.5806/AST.2022.35.1.24
(Chemistry Department, College of Science, Babylon University & Al-mustaqbal University College)
(Chemistry Department, College of Science, Babylon University)
(Chemistry Department, College of Science, Babylon University)
(Chemistry Department, College of Science, Babylon University)
(Chemistry Department, College of Science, Babylon University)
Ali,
F.
M.
, AN,
A.
, &
Kasim,
H.
K.
(2022). Spectrofluorometric quantification of Clozapine in pharmaceutical formulations and human plasma. Analytical Science and Technology, 35(1), 24-31, https://doi.org/10.5806/AST.2022.35.1.24
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Abstract
Herein, we present a simple, precise, accurate, and ultra-sensitive spectrofluorimetric method for estimation of clozapine (CLZ) in tablets and human plasma was developed and then validated. A highly fluorescent brown-yellowish fluorophore was formed (λex=469 nm, λemi=540 nm) as a nucleophilic substitution reaction occurred between CLZ and 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) in alkaline mcllavine buffer (pH 9.0). Optimum values of experimental parameters were carefully determined and optimized. The calibration curve was rectilinear over the concentration range of 80-900 ng mL−1 with a linear correlation coefficient (r =0.9984). The LOD and LOQ were determined to be 14 ng mL−1 and 42 ng mL−1, respectively. The proposed approach has been used successfully to quantification of Clozapine in its commercial formulations and human plasma.
- keywords
- clozapine, NBD-Cl, spectrofluorimetric, human plasma
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