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  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

  • P-ISSN1225-0163
  • E-ISSN2288-8985
  • SCOPUS, ESCI, KCI

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  • P-ISSN 1225-0163
  • E-ISSN 2288-8985

논문 상세

    An Analysis of the proteomics approach to the glycated peptides of human milk

    분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
    2022, v.35 no.1, pp.8-14
    https://doi.org/10.5806/AST.2022.35.1.8
    Seonghyeon Cho (College of Pharmacy, Gachon University,)
    Jong-Moon Park (College of Pharmacy, Gachon University)
    Jun Hwan Song (Department of Pediatrics, Soonchunhyang University)
    Nam Mi Kang (Department of Nursing, Konkuk University)
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    Abstract

    Many studies have shown that advanced glycation end-products (AGEs) and glycation adducts are significantly linked to aging and disease. Particularly, the level of glycation in human milk is important because the AGE intake is closely related to AGE levels in infants. In this study, we used human milk samples obtained from four primiparae and four multiparae. We isolated proteins using acetone and trichloroacetic acid (TCA) precipitation. A total of 67 glycated proteins and 122 glycated peptides was quantified; among them, 19 glycated peptides were differentially expressed. We confirmed that the degree of glycation differed according to fertility. The study provides a foundation for using proteomics to evaluate the mother’s milk quality and link between maternal health and human milk quality.

    keywords
    glycation, advanced glycation end-product, human milk, LC-MS/MS, fertility


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