- P-ISSN 1225-0163
- E-ISSN 2288-8985
- 권한신청
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
논문 상세
Home > 논문 상세
Quantitative determination of 2’-Hydroxy-3’,4’-methylenedioxy-3,4,5-trimethoxychalcone (HMTC) in rat plasma by HPLC-MS/MS and its application to a pharmacokinetic study
분석과학 / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2023, v.36 no.1, pp.53-58
https://doi.org/10.5806/AST.2023.36.1.53
(College of Pharmacy, Chung-Ang University)
(College of Pharmacy, Chung-Ang University)
(College of Pharmacy, Chung-Ang University)
(Faculty of Pharmaceutical Sciences, Nagasaki International University,)
(Department of Pharmacy, College of Pharmacy, Seoul National University)
(College of Pharmacy, Chung-Ang University)
(College of Pharmacy, Chung-Ang University)
(College of Pharmacy, Chung-Ang University)
(College of Pharmacy, Chung-Ang University)
(Faculty of Pharmaceutical Sciences, Nagasaki International University,)
(Department of Pharmacy, College of Pharmacy, Seoul National University)
(College of Pharmacy, Chung-Ang University)
(College of Pharmacy, Chung-Ang University)
Jihyun,
W.
,
Juhyung,
K.
,
Wonyoung,
P.
,
José,
C.
J.
M.
D.
S.
M.
,
Marc,
D.
,
Eunyoung,
K.
,
&
Wonku,
K.
(2023). . 분석과학, 36(1), 53-58, https://doi.org/10.5806/AST.2023.36.1.53
- 다운로드 수
- 조회수
Abstract
2’-Hydroxy-3’,4’-methylenedioxy-3,4,5-trimethoxychalcone (HMTC) is a newly synthesized chalcone that affects proliferation, cytotoxic potential and apoptosis in human leukemia cells. However, no validated determination method has been described so far for HMTC in biological samples. Thus, we developed a liquid chromatographic method using a tandem mass spectrometry to determine HMTC in rat plasma. Liquid-liquid extraction with ethyl acetate was used for the clean-up procedure. The analyte was separated on a reversedphase column with mobile phase of distilled water and acetonitrile (2:8, v/v, including 0.1 % formic acid). The ion transition of the precursor to the product ion was principally deprotonated ions [M-H]− at m/z 356.8 → 327.2 for HMTC. This analytical method was successfully applied in pharmacokinetic study of HMTC after intravenous administration in rats.
- keywords
- 2'-Hydroxy-3', 4'-methylenedioxy-3, 4, 5-trimethoxychalcone, HPLC-MS/MS, pharmacokinetics, rats
권호 내 다른 논문
- Green flow injection spectrophotometric system for lead ion (II) evaluation in vegetables samples using new azo reagent
- Identification of glycated peptides in human serum using LC-MS/MS: A comparison of data-dependent acquisition and Parallel reaction monitoring
- Discrimination of biological and artificial nicotine in e-liquid
- Novel stability indicating high-performance liquid chromatography method for the separation and simultaneous quantification of acalabrutinib and its impurities in pharmaceutical formulation
- An optimized cupric reducing antioxidant capacity (CUPRAC) method for assessment of xanthine oxidase inhibition activity
- Quantitative determination of 2’-Hydroxy-3’,4’-methylenedioxy-3,4,5-trimethoxychalcone (HMTC) in rat plasma by HPLC-MS/MS and its application to a pharmacokinetic study
- more
추천 논문
학술지 홈페이지 이용 환경은 크롬 브라우저 사용을 권장합니다.