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ISSN : 3022-6805

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Vol.2 No.4

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Effect of chloroform extract of traditional Dicranopteris linearis leaves against paracetamol- and CCl4-induced liver toxicity in rats

셀메드 / CELLMED, (P)3022-6805; (E)3022-6791
2012, v.2 no.4, pp.34-34
Syafawati Shamsahal Din (Universiti Putra Malaysia)
Siti Syariah Mamat (Universiti Putra Malaysia)
Noor Aisyah Ismail (Universiti Putra Malaysia)
Wan Noraziemah Wan Zainulddin (Universiti Putra Malaysia)
Zalina Zabidi (Universiti Putra Malaysia)
Farhana Yahya (Universiti Putra Malaysia)
Farah Hidayah Kamisan (Universiti Putra Malaysia)
Norhafizah Mohtarrudin (Universiti Putra Malaysia)
Fezah Othman (Universiti Putra Malaysia)
Zarizal Suhaili (Universiti Sultan Zainal Abidin)
Zainul Amiruddin Zakaria (Universiti Putra Malaysia)
Syafawati, S. D. , Siti, S. M. , Noor, A. I. , Wan, N. W. Z. , Zalina, Z. , Farhana, Y. , Farah, H. K. , Norhafizah, M. , Fezah, O. , Zarizal, S. , & Zainul, A. Z. (2012). . 셀메드, 2(4), 34-34.

Abstract

The present study aimed to determine the hepatoprotective activity of the chloroform extract of D. linearis leaves (CEDL) using the paracetamol (PCM)- and carbon tetrachloride (CCl4)-induced liver injury models in rats. The rats received dH2O (negative control), 200 mg/kg of silymarin (positive control) or CEDL (50, 250 and 500 mg/kg) orally once daily for 7 days and then were subjected to the hepatotoxic induction on the 7th day. The samples (i.e. blood and liver) were collected and underwent biochemical and microscopical analysis, respectively. From the data obtained, both inducers caused significant (p < 0.05) increase in the levels of AST and ALT when compared to the control group, which were significantly (p < 0.05) reduced by CEDL in a generally dose-dependent manner. These biochemical findings were supported by the histopathological analysis and histological scoring. In conclusion, CEDL possesses potential hepatoprotective activity, which could be associated with its flavonoid and tannin contents with the mechanisms of hepatoprotection linked to either its antioxidant or anti-inflammtory /immunomodulating activities. Further in-depth studies are required to identify the responsible bioactive compound.

keywords
Dicranopteris linearis, Gleicheniaceae, in vivo, hepatoprotective activity, chloroform extract, leaves

참고문헌

1.

Adewusi EA, Afolayan AJ. A review of natural products with hepatoprotective activity. J Med Plant Res. 2010;4:1318-1334.

2.

Akanitapichat P, Phraibung K, Nuchklang K, Prompitakkul S. Antioxidant and hepatoprotective activities of five eggplant varieties. Food Chem Toxicol. 2010;48:3017-3021.

3.

Chaudhary GD, Kamboj P, Singh I, Kalia AN. Herbs as liver savers - A review. Indian J Nat Prod Resour. 2010;1:397-408.

4.

Feroz Khan Z, Asdaq SMB, Prasanna Kumar SR. Effects of few Indian medicinal herbs on carbon tetrachloride induced hepatic injury in animals. Int J Pharm Tech Res. 2009;1:579-587.

5.

Guegenrich FP. Catalytic selectivity of human cytochrome P450 enzymes: Relevance to drug metabolism and toxicity. Toxicol Lett. 1994;70:133-138.

6.

Jamal P, Barkat AA, Amid A. Distribution of Phenolics in Various Malaysian Medicinal Plants. J Appl Sci. 2010;10:2658-2662.

7.

Kim SM, Kang K, Jho EH, Jung Y-J, Nho CW, Um B-H, Pan C-H. Hepatoprotective Effect of Flavonoid Glycosides from Lespedeza cuneata against Oxidative Stress Induced by tert-Butyl Hyperoxide. Phytother Res. 2011;25:1011-1017.

8.

Lee WM. Drug induced hepatotoxicity. N Engl J Med. 1995;333:1118-1127.

9.

Mathew L, Babu S. Phytotherapy in India: transition of tradition to technology. Curr Bot. 2011;2:26-30.

10.

Mohamed EA, Lim CP, Ebrika OS, Asmawi MZ, Sadikun A, Yam MF. Toxicity evaluation of a standardised 50% ethanol extract of Orthosiphon stamineus. J Ethnopharmacol. 2011;133:358-363.

11.

Mroueh M, Saab Y, Rizkallah R. Hepatoprotective activity of Centaurium erythraea on acetaminophen-induced hepatotoxicity in rats. Phytother Res. 2004;18:431-433.

12.

Popovic M, Kaurinovic B, Trivic S, Mimica-Dikic N, Bursa M. Effect of celery (Apium graveolens) extracts on some biochemical parameters of oxidative stress in mice treated with carbon tetrachloride. Phytother Res. 2006;20:531-537.

13.

Shimoda H, Tanaka J, Kikuchi M, Fukuda T, Ito H, Hatano T, Yoshida T. Walnut polyphenols prevent liver damage induced by carbontetrachloride and D-galactosamine: Hepatoprotective hydrolysable tannins in the kernel pellicles of walnut. J Agric Food Chem. 2008;56:4444-4449.

14.

Somchit MN, Zuraini A, Ahmad Bustaman A, Somchit N, Sulaiman MR, Noratunlina R. Protective activity of turmeric (Curcuma longa) in paracetamol-induced hepatotoxicity in rats. Int J Pharmacol. 2005;1:252-256.

15.

Wang R, Kong J, Wang D, Lien LL, Lien EJ. A survey of Chinese herbal ingredients with liver protection activities. Chin Med. 2007;2:5.

16.

Weber LWD, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: Carbon tetrachloride as a toxicological model. Crit Rev Toxicol. 2003;33:105-136.

17.

Zabidi Z, Wan Zainulddin WN, Mamat SS, Shamsahal Din S, Kamisan FH, Yahya F, Ismail NA, Rodzi R, Hussain H, Mohtarrudin N, Somchit MN, Zakaria ZA. Antiulcer Activity of Methanol Extract of Melastoma malabathricum Leaves in Rats. Med Princ Pract. 2012;21:501-503.

18.

Zakaria ZA, Abdul Ghani ZD, Raden Mohd Nor RN, Hanan Gopalan HK, Sulaiman MR, Abdullah FC. Antinociceptive and anti-inflammatory activities of Dicranopteris linearis leaves chloroform extract in experimental animals. Yakugaku Zasshi. 2006;126:1197-1203.

19.

Zakaria ZA, Ghani ZD, Nor RN, Gopalan HK, Sulaiman MR, Jais AM, Somchit MN, Kader AA, Ripin J. Antinociceptive, anti-inflammatory and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models. J Nat Med. 2008;62:179-187.

20.

Zakaria ZA, Mat Desa A, Ramasamy K, Ahmat N, Mohamad AS, Israf DA, Sulaiman MR. Lack of antimicrobial activities of Dicranopteris linearis extracts and fractions. Afr J Microbiol Res. 2010;4:71-75.

21.

Zakaria ZA, Mohamed AM, Mohd. Jamil NS, Rofiee MS, Somchit MN, Zuraini A, Arifah AK, Sulaiman MR. In vitro cytotoxic and antioxidant properties of the aqueous, chloroform and methanol extracts of Dicranopteris linearis leaves. Afr J Biotechnol. 2011a;10:273-282.

22.

Zakaria ZA, Rofiee MS, Mohamed AM, Teh LK, Salleh MZ. In vitro antiproliferative and antioxidant activities, and total phenolic contents of the extracts of Melastoma malabathricum leaves. J Acupunct Meridian Stud. 2011b;4:248-256.

23.

Zakaria ZA, Rofiee MS, Somchit MN, Zuraini A, Sulaiman MR, Teh LK, Salleh MZ, Long K. Hepatoprotective activity of dried- and fermented-processed virgin coconut oil. Evid Compliment Alt Med. 2011;2011:142739.

24.

Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16:109-110.

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