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The role of thymic stromal lymphopoietin on mast cell-mediated allergic inflammatory reactions

CELLMED / CELLMED, (P)3022-6805; (E)3022-6791
2016, v.6 no.3, pp.16-16
Tae-Yong Shin

Abstract

Thymic stromal lymphopoietin (TSLP) is a novel interleukin (IL)-7-like cytokine and was originally discovered in the supernatant of a murine thymic stromal cell line. TSLP signal initiates via complex of the TSLP receptor and the IL-7 receptor α chain. TSLP expression is closely connected with many diseases such as atopic dermatitis, allergic rhinitis, asthma, inflammatory arthritis, eosinophilic esophagitis, rheumatoid arthritis, inflammatory bowel diseases, and cancer. In this review, I discussed biological roles of TSLP on mast cell-mediated allergic responses. In addition, this review summarizes the effective drugs in allergic-inflammatory reactions induced by TSLP on mast cells.

keywords
thymic stromal lymphopoietin, atopic dermatitis, allergic rhinitis, mast cells

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