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ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
 

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조현병 환자의 청각적 시간지각의 결함

Deficits of auditory time perception in patients with schizophrenia

초록

본 연구는 동시/비동시 구별과제(Synchrony/Asynchrony discrimination; SA), 시간순서 판단과제(Temporal Order Judgment; TOJ)와 포괄적인 신경심리검사를 사용하여 조현병 환자의 청각적 시간지각과 신경심리 기능 간의 관련성을 알아보았다. SA 과제는 제시된 두 개의 음이 동시에 제시되었는지를 구별하는 과제이며, TOJ 과제는 제시된 두 개의 음 중 먼저 제시된 음이 높은 음인지 낮은 음인지를 판단하는 과제이다. 본 연구에는 조현병 환자 30명과 정상통제군 31명이 포함되었다. 연구 결과, 조현병 환자군은 정상통제군에 비해 두 시간지각 과제 모두에서 유의하게 더 낮은 정확률을 보였다. 아울러 SA 과제의 수행 수준과 주의 간의 정적 상관이 관찰되었다. 한편, TOJ 과제의 수행 수준은 주의, 시각 기억, 집행기능 간의 유의한 정적 상관이 관찰되었다. 또한, SA 과제의 수행 수준은 양성 및 음성증후군 척도로 측정한 P3(환각증상)과 유의한 부적 상관이, TOJ 과제의 수행 수준은 양성증상, P3, 일반정신병리, 총점과 유의한 부적 상관이 있음이 관찰되었다. 이 결과는 조현병 환자들이 청각적 시간지각에 결함을 가지고 있으며, 이 결함이 주의, 기억, 집행기능의 신경심리 기능과 더불어 조현병 증상과 유의한 관련이 있음을 시사한다.

keywords
schizophrenia, time perception, temporal order judgment task, synchrony/asynchrony discrimination task, 조현병, 시간지각, 시간순서 판단과제, 동시/비동시 구별과제, 신경심리검사

Abstract

This study investigated the relationships between auditory time perception and neuropsychological functions in patients with schizophrenia using Synchrony/Asynchrony discrimination (SA) task, Temporal Order Judgment (TOJ) task and comprehensive neuropsychological tests. Participants were asked to respond whether two tones were presented simultaneously or not in SA task, whereas in TOJ task, participants were asked to judge which tone was presented prior to the other tone. Thirty patients with schizophrenia and 31 normal controls participated in this study. The schizophrenia group showed significantly lower accuracy rates than did the control group in both SA and TOJ tasks. Performance on the SA task was positively correlated with attention., whereas performance on the TOJ task was positively correlated with attention, memory, executive function. Moreover, performances on the SA task were negatively associated with P3 (hallucination) symptom, and performances on the TOJ task were negatively associated with positive symptoms, P3, general psychopathology, and total score of the PANSS for schizophrenia. These findings suggest that patients with schizophrenia have deficits both in discriminating between synchrony and asynchrony, and judging temporal order. In addition, deficits of auditory time perception in patients with schizophrenia were significantly associated with schizophrenic symptoms and cognitive dysfucntions such as attention and executive dysfunctions.

keywords
schizophrenia, time perception, temporal order judgment task, synchrony/asynchrony discrimination task, 조현병, 시간지각, 시간순서 판단과제, 동시/비동시 구별과제, 신경심리검사

참고문헌

1.

김정기, 강연욱 (1999). 한국판-캘리포니아 언어 학습검사(K-CVLT). 서울: 도서출판 특수교육.

2.

염태호, 박영숙, 오경자, 김정규, 이영호 (1992). K-WAIS 실시요강. 서울: 한국가이던스.

3.

이중서, 안용민, 신현균, 안석균, 주연호, 김승현, 윤도준, 조경형, 구영진, 이지연, 조인희, 박영환, 김광수, 김용식 (2001). 한국판 양성 및 음성증후군 척도(Positive and Negative Syndrome Scale)의 신뢰도와 타당도. 신경정신분석의학, 40(6), 1090-1105.

4.

한오수, 안준호, 송선희, 조맹제, 김장규, 배재남, 조성진, 정범수, 서동우, 함봉진, 이동우, 박종익, 홍진표 (2000). 한국어 판 구조화 임상면담도구 개발: 신뢰도 연구. 신경정신의학, 39(2), 362-372.

5.

Allan, L. G. (1975). The relationship between judgments of successiveness. Perception & Psychophysics, 18(1), 29-36.

6.

Allman, M. J., & Meck, W. H. (2012). Pathophysiological distortions in time perception and timed performance. Brain, 135(3), 656- 677.

7.

Angrilli, A., Cherubini, P., Pavese, A., & Manfredini, S. (1997). The influence of affective factors on time perception. Perception & Psychophysics, 59(6), 972-982.

8.

Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: psychometric properties. Journal of Consulting and Clinical Psychology, 56(6), 893.

9.

Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561-571.

10.

Benton, A. L., Hamsher, K. D., & Sivan, A. B. (1994). Multilingual aphasia examination: manual of instructions. AJA Assoc.

11.

Boenke, L. T., Hoechenberger, R., Zeghbib, A., Alais, D., & Ohl, F. W. (2013). Interaction of spatial and temporal processing in the context of audio-visual synchrony judgment and temporal-order judgment. Perception European Conference on Visual Perception abstract, 42, 171.

12.

Brickenkamp, R. (1981). Concentration-endurance test manual. Verlag fur Psychologie, Gottingen.

13.

Burr, D., & Morrone, C. (2006). Time perception: space-time in the brain. Current Biology, 16(5), R171-R173.

14.

Carroll, C. A., Boggs, J., O’Donnell, B. F., Shekhar, A., & Hetrick, W. P. (2008). Temporal processing dysfunction in schizophrenia. Brain and Cognition, 67(2), 150-161.

15.

Capa, R. L., Duval, C. Z., Blaison, D., & Giersch, A. (2014). Patients with schizophrenia selectively impaired in temporal order judgments. Schizophrenia Research, 156(1), 51-55.

16.

Clegg, J., Brumfitt, S., Parks, R.W., Woodruff, P. W., 2007. Speech and language therapy intervention in schizophrenia: a case study. International Journal of Language and Communication Disorders 42, 81-101.

17.

Davalos, D. B., Kisley, M. A., & Ross, R. G. (2002). Deficits in auditory and visual temporal perception in schizophrenia. Cognitive Neuropsychiatry, 7(4), 273-282.

18.

Davalos, D. B., Kisley, M. A., & Ross, R. G. (2003). Effects of interval duration on temporal processing in schizophrenia. Brain and Cognition, 52(3), 295-301.

19.

De Boer-Schellekens, L., Stekelenburg, J. J., Maes, J. P., Van Gool, A. R., & Vroomen, J. (2014). Sound improves diminished visual temporal sensitivity in schizophrenia. Acta Psychologica, 147, 136-142.

20.

De Montalembert, M., Coulon, N., Cohen, D., Bonnot, O., & Tordjman, S. (2016). Time perception of simultaneous and sequential events in early-onset schizophrenia. Neurocase, 22(4), 392-399.

21.

Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. (1987). CVLT, California Verbal Learning Test: Adult Version: Manual. Psychological Corporation.

22.

Elvevåg, B., Brown, G. D., McCormack, T., Vousden, J. I., & Goldberg, T. E. (2004). Identification of tone duration, line length, and letter position: an experimental approach to timing and working memory deficits in schizophrenia. Journal of Abnormal Psychology, 113(4), 509.

23.

Farrell, S., & McLaughlin, K. (2007). Short-term recognition memory for serial order and timing. Memory & Cognition, 35(7), 1724-1734.

24.

First, M. B., Spitzer, R. L., Gibbson, M., & Williams, J. B. W. (1996). Structured clinical interview for DSM-IV Axis I disorder. New York State Psychiatric Institute; New York.

25.

Fostick, L., & Babkoff, H. (2013). Different response patterns between auditory spectral and spatial temporal order judgment (TOJ). Experimental Psychology, 60(6), 432.

26.

Foucher, J. R., Lacambre, M., Pham, B. T., Giersch, A., & Elliott, M. A. (2007). Low time resolution in schizophrenia: Lengthened windows of simultaneity for visual, auditory and bimodal stimuli. Schizophrenia Research, 97(1), 118-127.

27.

García-Pérez, M. A., & Alcalá-Quintana, R. (2012). On the discrepant results in synchrony judgment and temporal-order judgment tasks: a quantitative model. Psychonomic Bulletin & Review, 19(5), 820-846.

28.

Giersch, A., Lalanne, L., Corves, C., Seubert, J., Shi, Z., Foucher, J., & Elliott, M. A. (2009). Extended visual simultaneity thresholds in patients with schizophrenia. Schizophrenia Bulletin, 35(4), 816-825.

29.

Gómez, J., Jesús Marín-Méndez, J., Molero, P., Atakan, Z., & Ortuño, F. (2014). Time perception networks and cognition in schizophrenia: A review and a proposal. Psychiatry Research. 220(3), 737-744.

30.

Harris LR, Harrar V, Jaekl P, Kopinska A (2010). Mechanisms of simultaneity constancy. In: Nijhawan R(ed) Space and Time in Perception and Action. Cambridge University Press, Cambridge, UL, 232-253.

31.

Heaton, R. K., Chelune, G. J., Talley, J. L., Kay, G. G., & Curtiss, G. (1993). Wisconsin card sorting test manual revised and expanded. Lutz, FL: Psychological Assessment Resources

32.

Kay, S. R., Flszbein, A., & Opfer, L. A. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13(2), 261-276.

33.

Lalanne, L., van Assche, M., & Giersch, A. (2012). When predictive mechanisms go wrong: disordered visual synchrony thresholds in schizophrenia. Schizophrenia Bulletin, 38(4), 506-513.

34.

Lee, K. H., Bhaker, R. S., Mysore, A., Parks, R. W., Birkett, P. B., & Woodruff, P. W. (2009). Time perception and its neuropsychological correlates in patients with schizophrenia and in healthy volunteers. Psychiatry Research, 166(2), 174-183.

35.

Lezak, M. D. (1995). Neuropsychological Assessment, New York: Oxford University Press.

36.

Matthews, W. J., & Meck, W. H. (2016). Temporal cognition: Connecting subjective time to perception, attention, and memory. Psychological bulletin, 142(8), 865.

37.

Meck, W. H. (2005). Neuropsychology of timing and time perception. Brain and Cognition, 58(1), 1-8.

38.

Meyers, J. (1995). The Meyers scoring system for the Rey complex figure and the recognition trial: professional manual. Odessa, FL: Psychological Assessment Resources.

39.

Nishi, A., Yokoyama, M., Ogata, T., Nozawa, T., & Miyake, Y. (2011). The effect of voluntary movement on audio-haptic temporal order judgment. In 2011 IEEE/SICE International Symposium on System Integration(SII) (pp. 649-654).

40.

Osterrieth, P. A. (1944). The test of copying a complex figure: a contribution to the study of perception and memory. Archieves of Psychology, 30, 206-356.

41.

Papageorgiou, C., Karanasiou, I. S., Kapsali, F., Stachtea, X., Kyprianou, M., Tsianaka, E. I., et al. (2013). Temporal processing dysfunction in schizophrenia as measured by time interval discrimination and tempo reproduction tasks. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 40, 173-179.

42.

Paule, M. G., Meck, W. H., McMillan, D. E., McClure, G. Y., Bateson, M., Popke, E. J., et al. (1999). The use of timing behaviors in animals and humans to detect drug and/or toxicant effects. Neurotoxicology and Teratology, 21(5), 491-502.

43.

Peterburs, J., Nitsch, A. M., Miltner, W. H., & Straube, T. (2013). Impaired Representation of Time in Schizophrenia Is Linked to Positive Symptoms and Cognitive Demand. PloS one, 8(6), e67615.

44.

Reitan, R. M. (1958). Validity of the Trail Making Test as an indicator of organic brain damage. Perceptual and Motor Skills, 8(3), 271-276.

45.

Rey, A. (1941). L'examen psychologique dans les cas d'encéphalopathie traumatique. (Les problems.). Archives de Psychologie. 28, 286-340

46.

Roy, M., Grondin, S., & Roy, M. A. (2012). Time perception disorders are related to working memory impairment in schizophrenia. Psychiatry Research, 200(2), 159-166.

47.

Stroop, J. R. (1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology, 18(6), 643.

48.

Silverstein, A. B. (1989). Agreement between a short form and the full scale as a function of the correlation between them. Journal of Clinical Psychology, 45(6), 929-931.

49.

Sims, A., 1995. Symptoms in the Mind: An Introduction to Descriptive Psychopathology (2nded.). W.B. Saunders Company LTD, London.

50.

Szymaszek, A., Szelag, E., & Sliwowska, M. (2006). Auditory perception of temporal order in humans: The effect of age, gender, listener practice and stimulus presentation mode. Neuroscience Letters, 403(1), 190-194.

51.

Van Eijk, R. L., Kohlrausch, A., Juola, J. F., & Van de Par, S. (2008). Audiovisual synchrony and temporal order judgments: effects of experimental method and stimulus type. Perception & Psychophysics, 70(6), 955-968.

52.

Van Eijk, R. L., Kohlrausch, A., Juola, J. F., & Van De Par, S. (2010). Temporal order judgment criteria are affected by synchrony judgment sensitivity. Attention, Perception, & Psychophysics, 72(8), 2227-2235.

53.

Vatakis, A., Navarra, J., Soto-Faraco, S., & Spence, C. (2008). Audiovisual temporal adaptation of speech: temporal order versus simultaneity judgments. Experimental Brain Research, 185(3), 521-529.

54.

Vatakis, A., & Spence, C. (2006). Audiovisual synchrony perception for speech and music assessed using a temporal order judgment task. Neuroscience Letters, 393(1), 40-44.

55.

Waters, F., & Jablensky, A. (2009). Time discrimination deficits in schizophrenia patients with first-rank (passivity) symptoms. Psychiatry Research, 167(1), 12-20.

56.

Wittmann, M. (2011). Moments in time. Frontiers in Integrative Neuroscience, 5.

57.

Yamada, Y., & Kawabe, T. (2011). Emotion colors time perception unconsciously. Consciousness and Cognition, 20(4), 1835-1841.

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