- P-ISSN 1010-0695
- E-ISSN 2288-3339
Objective: This study was carried out to investigate the effect of Samooltang(SMT) on the injury or gastric mucuos membrane by ethanol in mice. Method: The normal group is that no inflammation elicited mice. The control group is that gastro-inflammation elicited mice by ethanol. The sample group is that SMT administered mice before gastro-inflammation elicitation. Results: In the immunohistochemical change, the distribution of SBA and COX-1 treated with SMT noticeably increased than the control group(p<0.05). The distribution of NF-κB P50, COX-2, and TUNEL treated with SMT noticeably decreased than the control group(p<0.05). And the distribution of SMT was as same as the normal group. Conclusion: According to the above results, it is suppose that SMT is applicable to gastritis and gastric ulcer by alcoholic drinks.
(1987) 소화성궤양에 대한 Famotidine 의 치료효과,
(1989) 소화성궤양에 대한 Nizatidine의 치료효과,
(2003) 스트레스와 에탄올로 유발된 mouse의 위점막 손상에 대한 귀비탕의 예방효과,
(1999) 갈화해성탕이 주상에 미치는 영향,
(1998) 中醫藥治療潰瘍性胃腸炎臨床觀察.,
(2001) 자호사물탕이 t-BHP로 유도된 간세포의 산화적 손상 및 자유기에 의한 지질과산화반응에 미치는 영향, 동국대학교 대학원
(1998) 사물탕 구성약물이 paeoniflorin의 흡수대사 및 장내미생물 효소활성에 미치는 영향, 경희대학교 대학원
(2000) Nitric oxide에 의해 유발된 C6 glial 세포독성에 대한 사물탕의 방어효과, 원광대학교 대학원
(1998) 사물탕이 L1210세포 및 항암제를 투여한 마우스의 면역세포에 미치는 영향, 우석대학교 대학원
(1997) 사군자탕 및 사물탕이 methotrexate로 유도된 흰쥐의 면역기능저하에 미치는 영향, 동국대학교 대학원
(1990) 주상의 관찰법에 대한 문헌적고찰,
(1993) 주상치료에 대한 문헌적 고찰,
(1993) 박승만 외 1인 술이 인체에 미치는 영향에 관한 동서의학적 고찰,
(1995) 사물탕의 항암제 부작용억제에 관한 실험적 연구, 경희대학교 대학원
(1992) 항암제 Mitomycin C의 부작용에 대한 수종 복합생약의 영향,
(2001) Arlt and Maarkus Leyh : Incidence and pathophysiology of peptic ulcer bleeding,
(2000) Graham : NSAID ulcers : prevalence and prevention,
(1998) Prostaglandins in the stomach ; an update,
(1998) Kimmey : Gastrointestinal side effects of nonsteroidal anti-inflammatory drug,
(1998) Siomon : Biology and toxic effects of nonsteroidal anti-inflammatory drugs,
(1998) The advent of highly selective inhibitors of cyclooxygenase-a review,,
(1998) Roles of COX-1 and COX-2 in gastrointestinal pathophysiology,
(1995) The heat-shock response,
(1984) Hsp 70 - Nuclear concentration during enviromental stress and cytoplasmic stroage during recovery,
(1998) Activation of gene growth facters and cyclooxygenases in rat gastric mucosa during recovery form stress damage,
(2000) Non-steroidal anti-inflammatory drugs and apoptosis in the gastrointestinal tract ; potential role of the pentose phosphate pathways,
(2001) Prolonged activation of mitogen-activated protein kinases during NSAID-induced apoptosis in HT-29 colon cancer cells,
(1998) IκB-NF-κB structure: at the interface of inflammation control, ,
(1996) NF-κB - Ten years after,
(1999) Lymphocyte migration in the intestinal mucosa transit and emigration of lymphoid cells and the influence of antigen,
(1998) Interleukin-15 and its role in chronic inflammatory diseases,
(2000) Physiology and pathophysiology of sphingolipid metabolism and signaling,
(1990) Alternation of gastric mucosal glycoprotein in gastric mucosa in stress ; A light and electron microscopic study,
(1994) Lectins are sensitive tools for defining the differentiation programs of mouse gut epithelial cell lineages,