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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

The Defensive Effect of Samooltang on Injury of Gastric Mucous Membrane of Mouse by Ethanol

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.3, pp.1-11


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Abstract

Objective: This study was carried out to investigate the effect of Samooltang(SMT) on the injury or gastric mucuos membrane by ethanol in mice. Method: The normal group is that no inflammation elicited mice. The control group is that gastro-inflammation elicited mice by ethanol. The sample group is that SMT administered mice before gastro-inflammation elicitation. Results: In the immunohistochemical change, the distribution of SBA and COX-1 treated with SMT noticeably increased than the control group(p<0.05). The distribution of NF-κB P50, COX-2, and TUNEL treated with SMT noticeably decreased than the control group(p<0.05). And the distribution of SMT was as same as the normal group. Conclusion: According to the above results, it is suppose that SMT is applicable to gastritis and gastric ulcer by alcoholic drinks.

keywords
Samooltang, mucous membrane, COX-1, NF-κB P50, COX-2, Samooltang, mucous membrane, COX-1, NF-κB P50, COX-2


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