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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

α2-Adrenoceptors are? Implicated in the Electroacupuncture-induced Analgesia in the Experimental Chronic Pain

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.3, pp.67-77



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Abstract

Objective : Many studies reported that acupuncture analgesia was mediated through the activation of peripheral and central opioid receptors. However, there is little electrophysiological study on the adrenergic mechanism of acupuncture analgesia in chronic inflammatory and neuropathic pain. The present study was undertaken to elucidate the role of adrenoceptors in the production of acupuncture analgesia in chronic pain model. Methods : In the rat with chronic inflammation and nerve injury, dorsal horn cell (DHC) responses to afferent C fiber stimulation were used as a pain index and changes in electroacupuncture (EA) analgesia were recorded before and after intravenous administration of selective adrenoceptor antagonists. EA stimulations (2Hz, 0.5msec, 3mA) were applied to the contralateral Zusanli point for 30 min. Results : EA stimulation induced long-lasting inhibition of DHC responses in the rat with chronic inflammation and nerve injury. In both models of inflammation and neuropathic pain, α-adrenoceptor antagonist (phentolamine) significantly attenuated an inhibitory effect of EA on DHC responses. Selective α2-adrenoceptor antagonist (yohimbine) also had a similar suppressive action on DHC responses to that of phentolamine. However, β-adrenoceptor antagonist (propranolol) did not have any inhibitory effect on DHC responses in both models of chronic pain. Conculsion : These experimental findings suggest that in the rat with chronic pain, EA stimulation with low frequency and high intensity produced an analgesic effect which was mediated through an activation of α2-adrenoceptors.

keywords
Chronic pain, Dorsal horn cell responses, Electroacupuncture, Adrenoceptors, Chronic pain, Dorsal horn cell responses, Electroacupuncture, Adrenoceptors


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