- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Therapeutic Effects of Extract of？ Uncariae Ramulis and Testudinis Plastrum on Cochlear Morphologic Change Induced by Salicylate Ototoxicity
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.3, pp.160-168
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(2004). Therapeutic Effects of Extract of？ Uncariae Ramulis and Testudinis Plastrum on Cochlear Morphologic Change Induced by Salicylate Ototoxicity. Journal of Korean Medicine, 25(3), 160-168.
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Abstract
Background and Objectives : Tinnitus is on the increase due to the increase in the elderly population, industrial pollution and noise pollution. This symptom is especially marked in patients with a hearing problem and the relationship between cause, mechanism and treatment is poorly understood. The characteristics of tinnitus and other hearing problems are well brought out using an animal model with salicylate ototoxicity. The therapeutic effects of Uncariae Ramulis and Testudinis Plastrum were expected in tinnitus and hearing problem; therefore we experimented on an animal model with salicylate ototoxicity. Salicylate is one of the most commonly prescribed drugs although it has been recognized that salicylate induces hearing loss and tinitus reversibly. The purpose of this study was to find out the therapeutic effects of this by the morphologic study using salicylate ototoxicity. Materials and Methods : Healty twelve Sprague-Dawley rats were divided into three groups : normal, control and sample. The sample group was treated with the extract of Uncariae Ramulis and Testudinis Plastrum (1cc/100g, once a day for 6days). And then, to induce the salicylate ototoxicity in the control and sample groups, rats were injected intraperitoneally with sodium salicylate (500mg/kg). We observed the morphologic changes in the cochlea of rats every 2, 3, 4 and 5 hours after injection. Results : The outer hair cells showed marked changes. Vacuolization formed in the cuticular plate and the endoplasm of the control group. The endoplasm and the cuticular plate of the sample group after 2 hours were similar to the control group. But the cuticular plate of the sample group observed after 3, 4 and 5 hours were not similar. Conclusion : The results suggest that an extract of Uncariae Ramulis and Testudinis Plastrum has therapeutic effects on an animal model with salicylate ototoxicity.
- keywords
- salicylate ototoxicity, Uncariae Ramulis and Testudinis Plastrum, tinitus, hearing loss, Morphologic change, salicylate ototoxicity, Uncariae Ramulis and Testudinis Plastrum, tinitus, hearing loss, Morphologic change
Reference
1
Coles RRA, (1981) Epidemiology of tinnitus: Tinnitus, Ciba Foundation Symposium 85, Pitman Books Ltd
2
구정완, (1999) 이명의 유병률 및 이명유무에 따른 청력역치수준,
3
백만기, (2001) 이비인후과학. , 일조각
4
Reed, (1960;71) An audiometric study of two hundred cases of subjective tinitus,
5
박찬일, (1999) 기니픽에서 Salicylate에 의한 유발이음향방사의 변화,
6
윤태현, (1995) 살리실산 나트륨 투여후 내이 외림프에서 글루탐산 농도의 변화,
7
김보형,, (2002) Cisplatin 투여후 시간경과에 따른 흰쥐와우의 형태학적 관찰,
8
조영채, (1995) 실험적으로 유도된 이독성 난청에서의 Ginko Extract의 효과, 경북대학교 의학과
9
박찬일, (1997) 은행잎 추출물이 Salicylate에 의한 청성뇌간유발반응역치 변화에 미치는 영향,
10
채병윤, (1997) 동의 안이비인후과학, 집문당
11
干祖望, (1999) 干氏 耳鼻咽喉口腔科學, 江蘇科學技術出版社
12
노석선, (1999) 원색 안이비인후과학, 일중사
13
김상호 ; 강형원 ; 유영수, (2002) 釣鉤藤이 βAPP 과발현 인간 신경아세포암에서의 항치매 효과에 관한 연구, 동의생리병리학회지
14
문상태, (2001) 釣鉤藤의 痙攣억제 및 睡眠증강 效果에 關한 硏究, 동국대학교 한의학과
15
김의태, (1990;5) 용담사간탕 및 조구등,하고초, 차전자 가미방이 고혈압에 미치는 영향,
16
김형수 ; 이용석 ; 오석규 ; 이강창 ; 이건목 ; 이정 ; 이상복 ; 김종호 ; 유준기 ; 강영성 ; 김성수 ; 송호준 ; 박승택, (2002) 조구등이 Glucose Oxidase로 손상된 대뇌신경세포에 미치는 효과, 동의생리병리학회지
17
문대환, (1990;5) 조구등 전탕액이 가토의 전정안구반사에 미치는 영향,
18
김재효, (2000) 조구등이 일측 전정기관 손상 흰쥐의 전정보상에 미치는 영향,
19
김성배, (1994;7) 난청의 원인 증상 치법에 대한 연구 중의잡지를 중심으로,
20
정찬호, (1995) 이명의 원인과 치법에 대한 연구( 중의잡지를 중심으로),
21
김혜정, (1990;3) 이명에 관한 문헌적 고찰,
22
최인화, (2001) 이명에 관한 임상적 연구,
23
하미경, (2003) 돌발성 난청 치료에 관한 임상적 고찰,
24
윤희성, (2003) 돌발성 난청 환자 치험 6례,
25
Jung TTK, (1993;26) Ototoxicity of salicylate,
26
Li XQ, (1988;36) Acute effects of noradrenalin related vasoactive agents on the ototoxicity of aspirine an experimental study in the guinea pig,
27
Jung TTK, (1995) Effect of leukotriene inhibitor on Cochlear blood flow in salicylate ototoxicity,
28
Stypulkowski PH, (1990;46) Mechanism of salicylate ototoxicity,
29
Hallworth R, (1997) Modulation of outer hair cell compliance and force by agent that affecting hearing,
30
Deer B, (jotolaryngol1982;11) Salicylate ototoxicity in the chinchilla,
31
Dodson HC, (1983;93) The effects of sodium salicylate on the cochlear of guinea pigs,
32
안영민, (1988;29) 살리실산 나트륨이 백서 와우의 미세구조에 미치는 영향에 관한 연구,
33
Brownell W, (1991;20) Concomitant salicylate-induced alterations of outer hair cell subsurface cisternae and electromotility,
34
Kay IS, (1993;250) The effect of nimodipine on salicylate ototoxicity in the rat as revealed by the auditory evoked brain-stem response,
35
Gold A, (1966;76) Studies in auditory adaptation Some effects of sodium salicylate on evoked auditory potentials in cats,
36
Hansen R, (1986;112) Differential uptake of salicylates in serum,
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