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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

Study on the Effect of Gamisihotang(GSHT) on Gultamate Receptor, Free Radical and Brain Damage in Rats Subjected to Brain Ischemia

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.3, pp.32-44





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Abstract

Objective : This study was investigated to prove the effect of GSHT on the gultamate receptor, free radical and brain damage in rats subjected to brain ischemia. Methods : Level of cultured cortical neuron death caused by toxic chemicals were measured by LDH release assay. Neuroprotective effects of GSHT on brain tissues were examined in vivo by ischemic model of middle cerebral artery(MCA) occlusion.Results : GSHT showed significant inhibitory effect of GSHT on LDH release induced by NMDAkinateFe2+. GSHT decreased remarkably coma duration time in a infatal dose of KCN and showed survival rate in a fatal dose. GSHT decreased remarkably ischemic area and edema induced by the MCA blood flow block. GSHT showed high improvement of forelimb and hindlimb test after MCA occulusion in neurological exemination. GSHT showed no significant change after MCA occulusion in pathological observation as normal group.Conclusion : These results indicate that GSHT can be used in the brain damage sujected to Brain Ischemia. Further study will be needed about the functional mechanism and etc..

keywords
Gamisihotang(GSHT), Gultamate receptor, Free radical, Brain damage, Gamisihotang(GSHT), Gultamate receptor, Free radical, Brain damage


Reference

1

統計廳, (2001) 死亡原因統計年譜, 통계청

2

이정아, (2000) 뇌졸중후 우울증과 일상생활 수행능력과의 상관관계,

3

아담스 신경과학 편찬위원회 역, (1998) 아담스 신경과학, 도서출판 정담

4

이중달 역, (1991) 그림으로 설명한 병리학, 고려의학

5

Schubert J, (1986;162) Antagonism of experimental cyanide toxicity in relation to the in vivo activity of cytochrome oxidase,

6

Nagasawa H, (1989;20) Correlation between cerebral blood flow and histologic changs in a new rat model of middle cerebral artery occlusion,

7

정혜주, (1994;7) 뇌허혈 동물모델을 이용한 뇌기능개선제의 효능에 관한 연구 국립보건안전연구원보,

8

Pitts LH, (1986;17) Evaluation of the model and development of a neurologic examination,

9

김종성, (1998) 뇌졸중의 모든 것, 도서출판 정담

10

설인찬, (1998) 補陽還五湯이 高脂血症, 血栓, 高粘度血症, 高血壓 및 腦損傷에 미치는 影響.,

11

안택원, (1999) 加味通栓化瘀湯이 血栓 腦虛血 및 腦損傷에 미치는 影響, 大田大學校 大學院

12

홍 석, (1999) 加味天麻鉤藤飮의 血栓症 및 腦損傷에 對한 實驗的 硏究, 大田大學校 大學院

13

강순희 외, (1995) 淸泡逐瘀湯 및 蜂毒이 瘀血病態模型에 미치는 影響,

14

최 현 외, (1991;11) 中風의 瘀血論的 考察 및 活血化瘀法에 의한 治療 近況,

15

채창희, (2000) 흰쥐에서 일시적 국소 뇌허혈에 미치는 Glutamate의 역할,

16

임소영, (1999) Nitric Oxide Synthase의 억제가 전뇌허혈/재관류시 Hydroxyl Radical 생성에 미치는 영향,

17

최규택, (1999) 뇌허혈 발생전 K+ 통로 조작이 해마의 [K+] 및 Glutamate 농도에 미치는 영향,

18

이귀녕, (2000) 임상병리파일(3th/Edition). , 의학문화사

19

임승민 ; 안정조 ; 최영 ; 오병열 ; 유호룡 ; 김윤식 ; 설인찬, (2002) 三氣飮과 通痺飮이 腦損傷 및 血栓에 미치는 영향,

20

유종삼, (2003) 加味散이 高血壓 및 腦損傷에 미치는 영향,

21

Black K, (1996) Blood-Brain Barrier in Youmans,

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