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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

The Efficacy of Sihocheonggan-san(Chaihuqinggan-san) Extract to Improve he Function of Stratum Corneum on Mice Model after Atopic Dermatitis Elicitation

Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.3, pp.137-148


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Abstract

Objective : Administering the Sihocheonggan-san(SC) extract on to the control (CON) is to study change of external dermal formation, change of leukocytes in vasculature, change of lipid formation in stratum corneum and distribution of ceramide and this study is done through forcing injury to mice's back skin which are lipid protect formation in stratum corneum. Materials and Methods : The CON which caused intentionally using the external application on the mice's back skin was used the SC. The change of leukocytes in vasculature has been identified through optima 5.2 and student t-test and the results were made into dermal foramtion graph. Results : After dispensing SC extract into the CON, the dermal injury was decreased. Especially, recover of lipid protection formation which include lipid and ceramide in stratum corneum is suppressing acute inflammation that some factors are PKC, TNF-α, IL-12B which controled the secretion of relating inflammatory cytokine, also went onto decrease of angiogenesis, and the decrese of degranulated mast cell. In addition, the decrease of epithelial injury also caused the growth of cell to decrease in stratum basale and cytoclasis. In the vasculature, the leukocytes were also decreased and it could relate to decrease CON. Conclusion : Thus, SC has effect on CON suppressing the dermal injury through recovering of lipid protection formation in stratum corneum.

keywords
atopic dermatitis, Sihocheonggan-san, lipid protection, ceramide, atopic dermatitis, Sihocheonggan-san, lipid protection, ceramide


Reference

1

강석영, (1993) 알레르기 질환의 진단과 치료, 일조각

2

박윤기, (1993) 흔히 보는 피부질환 진단과 치료,

3

공남미, (1999) 아토피 피부염의 양한방적 고찰,

4

김윤희, (1993;7) 아토피성 피부염에 관한 동서의학적 고찰,

5

조용주, (1994;15) 아토피 피부염의 발생부위에 관한 고찰,

6

방형돈, (1998) 아토피피부염 환자에 대한 thymopentin의 치료 효과 천식 및 알레르기,

7

차미경, (1994;14) 아토피 피부염에서 eosinophil catinic protein의 변화,

8

이영진, (1995) 아토피 피부염의 중증도와 혈청 ECP치 및 가용성 IL-2 수용체지 사이의 상관관계와 Thymopentin 치료에 따른 변화,

9

최현주, (1999) 아토피피부염 환자에서 집먼지 진드기 항원-자가항체 면역 복합치료효과,

10

김진우, (1995) 아토피 피부염에 대한 환경인자의 영향,

11

노석선, (1991;4) 當歸飮子 수출액이 항 Allergy 반응과 Mouse의 면역세포기능에 미치는 영향,

12

이승희, (2000) 補肺定喘湯을 이용한 아토피 피부염 치료에 관한 임상연구c,

13

남봉수, (2000) 아토피 피부염에 대한 임상적 연구,

14

최인화, (1991;12) 아토피 피부염에 관한 임상적 연구,

15

박혜선, (2000) 아토피 피부염의 중의 외치법 고찰,

16

정찬호, (1995) 아토피 피부염에 대한 단식 치험 2례,

17

이현우, (2002) 生血潤膚飮이 아토피 피부염을 유발한 동물모델의 각질층 기능회복에 미치는 영향,

18

矢數格, (1996) 漢方一貫堂醫學, 의학연구사

19

강원형, (2002) 피부질환 아틀라스,

20

Akiyama H, (1994;104) Detection of very slow-growing methicillin-resistant Staphylococcus aureus in skin lesion of AD patient Japan J Dermatol,

21

Andrea H, (2000) Physiology and pathophysiology of sphingolipid metabolism and signaling,

22

Bunikowski R,, (2000) Evidence for a disease promoting effect of Staphylococcus aureus-derived exotoxins in AD,

23

Christophers E. , (1995) The inflammatory infiltrate in psoriasis,

24

Donald Y. M, (2003) . Atopic dermatitis,

25

Elias P. M.,, (1984;74) Straum corneum lipids in disorders of cornification,

26

Gopinathan K. M, (2002) New insights into skin structure: Scratching the surface,

27

Feinglod K. R, (1998) The regulation and role of epidermal lipid synthesis,

28

Hunnum Y, (1989;243) Function of sphingolipid breakdown productionin cellular regulation,

29

Minehiro O,, (2002) Detergent-induced epidermal barrier dysfunction and its prevention,

30

Motta S, (1994;130) Abnormality of water barrier function in psoriasis,

31

Paige D, (1994;131) Quantification of stratum corneum ceramides and lipid envelope ceramide in the hereditary ichthyoses,

32

Yoshida S, (1997) Involvement of IL-8 vascular endothelial growth factor and basic fibroblast growth factor in TNF-a dependent angiogenesis,

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