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E-ISSN : 2733-4538
The purpose of this study was to investigate the differences in neuropsychological characteristics and the conversion rate to dementia between early onset MCI (EOMCI) and late onset MCI (LOMCI) patients. We enrolled 150 patients with MCI (59 EOMCI, 91 LOMCI). At baseline, EOMCI obtained significantly higher scores in confrontational naming and semantic word fluency test than LOMCI. Compared to baseline, the follow-up data showed that the immediate recall score for visual memory was improved in EOMCI but declined in LOMCI. The annual conversion rate was 9.8% in EOMCI and 17.5% in LOMCI. To predict the conversion from MCI to dementia, we also compared the baseline neuropsychological data between converters and non-converters within the groups. The converters performed significantly low in memory tests in both MCI groups and the EOMCI converters showed additional impairment in semantic word fluency. This study suggests that EOMCI may differ from LOMCI in terms of patterns of cognitive impairment and that EOMCI may be a heterogeneous group, which includes patients with not only a prodromal state of EOAD but also cognitive impairment due to various problems such as depression.
강연욱, 나덕렬 (2003). 서울신경심리검사(SNSB). 인천: Human Brain Research & Consulting co.
강연욱, 나덕렬, 한승혜 (1997). 치매환자들을 대상으로 한 K-MMSE의 타당도 연구. 대한신경과학회지, 15(2), 300-308.
구형모, 김지혜, 권의정, 김성환, 이형석, 고혜정 등 (2004). 일상활동평가-복합(Seoul- Instrumental Activities of Daily Living; S- IADL)의 신뢰도 및 타당도 연구. 대한신경정신의학회, 43(2), 189-199.
김지혜, 신민영, 윤지혜, 안인숙 (2006). MCI의 정의: 최근 제안된 정의에 근거한 MCI의 임상적 효율성에 대한 연구. 한국심리학회 연차학술발표대회 논문집, 2006, 2-3.
김홍근, 김용숙, 김태유 (2011). 한국 노인의 연령, 교육수준, 성별이 인지기능 측정치들에 미치는 효과. 한국심리학회지: 임상, 30(3), 681-701.
석정서, 최진영, 김호영 (2010). 한국판 치매 평가 검사(K-DRS)의 2차 규준 연구. 한국심리학회지: 임상, 29, 559-572.
안효정, 최진영 (2004). 노인용 이야기 회상 검사의 표준화 연구. 한국심리학회지: 임상, 23, 435-454.
정인과, 곽동일, 신동균, 이민수, 이현수, 김진영 (1997). 노인 우울 척도(Geriatric Depression Scale)의 신뢰도, 타당도 연구. 신경정신의학, 36(1), 103-111.
최진영, 이지은, 김명진, 김호영 (2006). 노인용 언어 학습 검사(Elderly Verbal Learning Test)의 개발 및 표준화 연구. 한국심리학회지: 일반, 25, 141-173.
Bigio, E. H., Hynan, L. S., Sontag, E., Satumtira, S., & White, C. L. (2002). Synapse loss is greater in presenile than senile onset Alzheimer disease: Implications for the cognitive reserve hypothesis. Neuropathology and Applied Neurobiology, 28, 218-227.
Chui, H. C., Teng, E. L., Henderson, V. W., & Moy, A. C. (1985). Clinical subtypes of dementia of the Alzheimer type. Neurology, 35, 1544-1550.
Dierckx, E., Engelborghs, S., De Raedt, R., Van Buggenhout, M., De Deyn, P. P., Verté, D., et al. (2009). Verbal cued recall as a predictor of conversion to Alzheimer's disease in mild cognitive impairment. International Journal of Geriatric Psychiatry, 24(10), 1094- 1100.
Filley, C. M., Kelly, J., & Heaton, R. K. (1986). Neuropsychologic features of early-and late- onset Alzheimer’s disease. Archives of Neurology, 43, 574-576.
Fischer, P., Jungwirth, S., Zehetmayer, S., Weissgram, S., Hoenigschnabl, S., Gelpi, E., et al. (2007). Conversion from subtypes of mild cognitive impairment to Alzheimer dementia. Neurology, 68(4), 288-291.
Fratiglioni, L. (1996). Epidemiology of Alzheimer's disease and current possibilities for prevention. Acta Neurologica Scandinavica, 165, 33-40.
Ganguli, M., Dodge, H. H., Shen, C., & DeKosky, S. T. (2004). Mild Cognitive Impairment, amnestic type: An epidemiologic study. Neurology, 63, 115-121.
Ganguli, M., Snitz, B. E., Lee, C. W., Vanderbilt, J., Saxton, J. A., & Chang, C. C. (2010). Age and education effects and norms on a cognitive test battery from a population-based cohort: The Monongahela-Youghiogheny Healthy Aging Team. Aging and Mental Health, 14(1), 100-107.
Greicius, M. D., Geschwind, M. D., & Miller, B. L. (2002). Presenile dementia syndromes: An update on taxonomy and diagnosis. Journal of Neurology, Neurosurgery & Psychiatry, 72, 691- 700.
Grober, E., Lipton, R., Hall, C., & Crystal, H. (2000). Memory impairment on free and cued selective reminding predicts dementia. Neurology, 54, 827-832.
Hodges, J. R. (2006). Alzheimer's centennial legacy: Origins, landmarks and the current status of knowledge concerning cognitive aspects. Brain, 129, 2811-2822.
Hofman, A., Rocca, W. A., Brayne, C., Breteler, M. M., Clarke, M., Cooper, B., et al. (1991). The prevalence of dementia in Europe: A collaborative study of 1980-1990 findings. International journal of epidemiology, 20(3), 736 -748.
Jacobs, D., Sano, M., Marder, K., Bylsma, F., Lafleche, G., Albert, M., et al. (1994). Age at onset of Alzheimer's disease: Relation to pattern of cognitive dysfunction and rate of decline. Neurology, 44, 1215-1220.
Jorm, A. F., Korten, A. E., & Henderson, A. S. (1987). The prevalence of dementia: A quantitative integration of the literature. Acta Psychiatric Scandinavica, 76(5), 465-479.
Kim, E. J., Cho, S. S., Jeong, Y., Park, K. C., Kang, S. J., Kang, E., et al. (2005). Glucose metabolism in early onset versus late onset Alzheimer's disease: An SPM analysis of 120 patients. Brain, 128, 1790-1801.
Kim, S. H., Seo, S. W., Yoon, D. S., Chin, J., Lee, B. H., Cheong, H. K., et al. (2010). Comparison of neuropsychological and FDG- PET findings between early-versus late-onset mild cognitive impairment: A five-year longitudinal study. Dementia and Geriatric Cognitive Disorders, 29(3), 213-223.
Koedam, E. L., Lauffer, V., van der Vlies, A. E., van der Flier, W. M., Scheltens, P., & Pijnenburg, Y. A. (2010). Early-versus late- onset Alzheimer’s disease: More than age alone. Journal of Alzheimer’s Disease, 19, 1401-1408.
Ku, H. M., Kim, J. H., Kwon, E. J., Kim, S. H., Lee, H. S., Ko, H. J., et al. (2004). A study on the reliability and validity of Seoul- Instrumental Activities of Daily Living (S- IADL). Journal of Korean Neuropsychiatric Association, 43, 189-199.
Licht, E. A., McMurtray, A. M., Saul, R. E., & Mendez, M. F. (2007). Cognitive differences between early- and late-onset Alzheimer’s disease. American Journal of Alzheimer’s Disease & Other Dementias, 22, 218-222.
Mayeux, R., Ottman, R., Tang, M. X., Noboa- Bauza, L., Marder, K., Gurland, B., et al. (1993). Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community-dwelling elderly persons and their first-degree relatives. Annals of Neurology, 33(5), 494-501.
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34(7), 939-944.
Perri, R., Serra, L., Carlesimo, G. A., Caltagirone, C. (2007). Amnestic mild cognitive impairment: Difference of memory profile in subjects who converted or did not convert to Alzheimer's disease. Neuropsychology, 21(5), 549- 558.
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999). Mild Cognitive Impairment: Clinical characterization and outcome. Archives of Neurology, 56, 303-308.
Petersen, R. C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256(3), 183-194.
Reid, W., Broe, G., Creasey, H., Grayson, D., McCusker, E., Bennett, H., et al. (1996). Age at onset and pattern of neuropsychological impairment in mild early-stage Alzheimer disease: A study of a community-based population. Archives of Neurology, 53, 1056- 1061.
Rountree, S. D., Waring, S. C., Chan, W. C., Lupo, P. J., Darby, E. J., & Doody, R. S. (2007). Importance of subtle amnestic and nonamnestic deficits in mild cognitive impairment: Prognosis and conversion to dementia. Dementia and Geriatric Cognitive Disorders, 24(6), 476-482.
Sarazin, M., Berr, C., De Rotrou, J., Fabrigoule, C., Pasquier, F., Legrain, S., et al. (2007). Amnestic syndrome of the medial temporal type identifies prodromal AD: A longitudinal study. Neurology, 69(19), 1859-1867.
Seltzer, B., & Sherwin, I. (1983). A Comparison of clinical features in early- and late-onset primary degenerative dementia: One entity or two? Archives of Neurology, 40, 143-146.
Stern, Y. (2002). What is cognitive reserve? Theory and research application of the reserve concept. Journal of the International Neuropsychological Society, 8, 448-460.
Stern, Y. (2006). Cognitive reserve and Alzheimer disease. Alzheimer Disease and Associated Disorders, 20, 112-117.
Stern, Y., Alexander, G. E., Prohovnik, I., Stricks, L., Link, B., Lennon, M. C., et al. (1995). Relationship between lifetime occupation and parietal flow: Implication for reserve against Alzheimer's disease pathology. Neurology, 45(1), 55-60.
Sulway, M. R. (1996). Age at onset and pattern of neuropsychological impairment in mild early-stage Alzheimer disease: A study of a community-based population. Archives of Neurology, 53, 1056-1061.
Suribhatla, S., Baillon, S., Dennis, M., Marudkar, M., Muhammad, S., Munro, D., et al. (2004). Neuropsychological performance in early and late onset Alzheimer’s disease: Comparisons in a memory clinic population. International Journal of Geriatric Psychiatry, 19, 1140-1147.
Tabert, M. H., Manly, J. J., Liu, X., Pelton, G. H., Rosenblum, S., Jacobs, M., et al. (2006). Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment. Archives of General Psychiatry, 63, 916-924.
van der Flier, W. M., Pijnenburg, Y. A., Fox, N. C., & Scheltens, P. (2011). Early-onset versus late-onset Alzheimer's disease: The case of the missing APOE ɛ4 allele. The Lancet Neurology, 10, 280-288.
van der Vlies, A. E., Koedam, E. L., Pijnenburg, Y. A., Twisk, J. W., Scheltens, P., & van der Flier, W. M. (2009). Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset. Psychological Medicine, 39, 1907-1911.
Visser, P. J., Kester, A., Jolles, J., & Verhey, F. (2006). Ten-year risk of dementia in subjects with mild cognitive impairment. Neurology, 67, 1201-1207.