E-ISSN : 2733-4538
The purpose of this study was to investigate the differences in neuropsychological characteristics and the conversion rate to dementia between early onset MCI (EOMCI) and late onset MCI (LOMCI) patients. We enrolled 150 patients with MCI (59 EOMCI, 91 LOMCI). At baseline, EOMCI obtained significantly higher scores in confrontational naming and semantic word fluency test than LOMCI. Compared to baseline, the follow-up data showed that the immediate recall score for visual memory was improved in EOMCI but declined in LOMCI. The annual conversion rate was 9.8% in EOMCI and 17.5% in LOMCI. To predict the conversion from MCI to dementia, we also compared the baseline neuropsychological data between converters and non-converters within the groups. The converters performed significantly low in memory tests in both MCI groups and the EOMCI converters showed additional impairment in semantic word fluency. This study suggests that EOMCI may differ from LOMCI in terms of patterns of cognitive impairment and that EOMCI may be a heterogeneous group, which includes patients with not only a prodromal state of EOAD but also cognitive impairment due to various problems such as depression.
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