This study was conducted to identify profiles of loners and those likely to suffer academic burnout among middle school students and to determine whether these profiles differed by gender, ego-resilience, ego-weakness, and school adaptation. The participants in this study were 270 middle school students in Kyung-nam. The results showed that there were four main profiles of students related to their likelihood of being loners and suffering academic burnout: the adaptive group, which had a low tendency towards both loneliness and academic burnout; the burnout group, which had a high tendency towards academic burnout but a low tendency towards loneliness; the lonely group, which had a high tendency towards loneliness but a low tendency towards academic burnout; and the loner-burnout group, which had high tendencies towards both loneliness and academic burnout. Cross-tabulation and one-way ANOVA analyses of the four groups showed that the loneliness-burnout group had a statistically lower level of ego-resilience, higher level of ego-weakness, and lower level of school adaptation than the other groups. This paper discusses the implications for counseling middle school students and presents suggestions for future research.