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- E-ISSN 2288-8985
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Separation of Functionalized Heterocyclic Compounds by High Performance Liquid Chromatography(I)
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1997, v.10 no.6, pp.408-417
Lee,
K., Cho,
Y. J., &
Lee,
Y.
C.
(1997). Separation of Functionalized Heterocyclic Compounds by High Performance Liquid Chromatography(I). Analytical Science and Technology, 10(6), 408-417.
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Abstract
Normal phase or reversed phase liquid chromatographic separation of some structural isomers of functionalized heterocyclic compounds has been carried out by using several different columns and various mobile phases. The optimal experimental conditions for separation of structural isomers were found on a ternary solvent system including alcohol as a modifier. This polar modifier is preferentially adsorbed onto strong adsorption site, leaving a more uniform population of weaker site that then serve to retain the sample. This 'deactivation' of the adsorbent leads to a number of improvements in subsequent separations. The optimal mobile phase system of separation were found on normal phase on structural isomers. Retention mechanism of normal phase system was also studied depending on adsorption strength between solute and stationary phase of column. However, retention factors of reversed phase system were found on hydrophobic interaction with solvophobic effect.
- keywords
- ternary solvent system, functionalized heterocyclic compound, reversed phase, hydrophobic interaction
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