- P-ISSN 1225-0163
- E-ISSN 2288-8985
정신질환 치료에 가장 폭넓게 사용되는 haloperidol(HAL)의 혈중농도 분석법이 개발되었다. 이 연구를 위하여 gas chromatography/nitrogen-phosphorus detection(GC/NPD)을 이용하였으며, bromoperidol을 내부표준물질로 사용하였고, 시료전처리 방법으로써 diethylether를 추출용매로 사용하는 3단계 추출법을 사용하였다. 이 과정에 있어서 추출효율은 15 ng/mL에서 <TEX>$67.5{\pm}1.9%$</TEX>이었고, 1~40 ng/mL 범위에서 상관계수 <TEX>$r^2
Analytical method of haloperidol (HAL) in serum which has been widely used in therapy of schizophrenic disorders is developed. Gas chromatography/nitrogen-phosphorus detection (GC/NPD) was used for this study. Bromoperidol was used as an internal standard and diethylether as a solvent of three-step extraction. The extraction yield in this procedure was <TEX>$67.5{\pm}1.9%$</TEX> at 15 ng/mL. A good linear response in the range of 1~40 ng/mL was obtained with correlation coefficient of <TEX>$r^2