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- E-ISSN 2288-8985
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Determination of Haloperidol Serum Levels in Psychiatric Patients with Gas Chromatography-Nitrogen Phosphorus Detection
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1998, v.11 no.3, pp.161-166
Paik,
M., Kang,
B., Lee,
K., &
Shin,
H.
(1998). Determination of Haloperidol Serum Levels in Psychiatric Patients with Gas Chromatography-Nitrogen Phosphorus Detection. Analytical Science and Technology, 11(3), 161-166.
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Abstract
Analytical method of haloperidol (HAL) in serum which has been widely used in therapy of schizophrenic disorders is developed. Gas chromatography/nitrogen-phosphorus detection (GC/NPD) was used for this study. Bromoperidol was used as an internal standard and diethylether as a solvent of three-step extraction. The extraction yield in this procedure was <TEX>$67.5{\pm}1.9%$</TEX> at 15 ng/mL. A good linear response in the range of 1~40 ng/mL was obtained with correlation coefficient of <TEX>$r^2
- keywords
- Haloperidol, Serum, GC-NPD, Trace analysis
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