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  • P-ISSN 1225-0163
  • E-ISSN 2288-8985

Determination of Haloperidol Serum Levels in Psychiatric Patients with Gas Chromatography-Nitrogen Phosphorus Detection

Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1998, v.11 no.3, pp.161-166
Paik, Man-Jeong
Kang, Bo-Kyoung
Lee, Kyoung-Ok
Shin, Ho-Sang
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Abstract

Analytical method of haloperidol (HAL) in serum which has been widely used in therapy of schizophrenic disorders is developed. Gas chromatography/nitrogen-phosphorus detection (GC/NPD) was used for this study. Bromoperidol was used as an internal standard and diethylether as a solvent of three-step extraction. The extraction yield in this procedure was <TEX>$67.5{\pm}1.9%$</TEX> at 15 ng/mL. A good linear response in the range of 1~40 ng/mL was obtained with correlation coefficient of <TEX>$r^2

keywords
Haloperidol, Serum, GC-NPD, Trace analysis


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