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Changes of Endogenous Steroids Profile After Oral Administration of Danazol
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1998, v.11 no.5, pp.353-359
Choi,
M. H., &
Chung,
B.
C.
(1998). Changes of Endogenous Steroids Profile After Oral Administration of Danazol. Analytical Science and Technology, 11(5), 353-359.
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Abstract
Danazol, one of the IOC banned substances, is a synthetic steroid which stimulates the synthesis of cellular protein with multiple and diverse biologic effects. To confirm the androgenic effects of danazol, levels of eight endogenous steroids and its major metabolite in human urine were simultaneously analyzed by selected ion monitoring (SIM) of GC/MS after oral administration. The recovery range of this method was 71.59%~93.56% and the RSD values of precision and accuracy test were 1.87%~10.48% and 1.32%~11.25%, respectively. The limits of detection of most of the drugs were <TEX>$0.01{\sim}0.05{\mu}g/mL$</TEX> and calibration was carried out using urine spiked with each endogenous steroid and ethisterone standard at a concentration of 0.1, 0.5, 1.0, 10, 20 and <TEX>$50{\mu}g/mL$</TEX> and with <TEX>$10{\mu}g/mL$</TEX> of internal standard. Correlation coefficients varied between 0.963 and 0.991. The endogenous steroid profiling is one of valuatle tool for decteation of anabolic steroids.
- keywords
- danazol, ethisterone, endogenous steroids, urinary metabolite, GC/MS
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