- P-ISSN 1225-0163
- E-ISSN 2288-8985
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
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Fundamental Investigation of Non-invasive Determination of Alcohol in Blood by Near Infrared Spectrophotometry
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1999, v.12 no.5, pp.375-381
Chang,
S., Cho,
C., Woo,
Y., Kim,
H., Kim,
Y., Lee,
K., Kim,
Y., &
Park,
S.
(1999). Fundamental Investigation of Non-invasive Determination of Alcohol in Blood by Near Infrared Spectrophotometry. Analytical Science and Technology, 12(5), 375-381.
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Abstract
Near infrared spectrophotometry(NIR) was developed as a non-invasive determination of blood alcohol. The first pure alcohol/water samples were prepared with ethanol concentration from 0.01 to 0.1%(w/w). Analysis of the second-derivative data was accomplished with multilinear regression(MLR). The standard error of calibration(SEC) of ethanol in ethanol/water solutions was approximately 0.0039%. The calibration models were established from the blood alcohol spectra by MLR and PLSR analysis. The best calibration was built with the second-derivative spectra of 2266 and 2326 nm by MLR. Second-derivative spectra in the spectral ranges of 1100~1340, 1500~1796 and 2064~2300 nm with four PLSR factors provided the standard error of prediction(SEP) of 0.030%(w/w). These results indicate that NIR may be applied for a fast non-invasive determination of alcohol in the blood.
- keywords
- near infrared spectrophotomeuy(NIR), non-invasive determination, alcohol, multiple linear regression(MLR), panial least squares regression(PLSR)
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