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A study of the metabolites for 7-keto-DHEA-acetate in human urine (II)
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2004, v.17 no.5, pp.401-409
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(2004). A study of the metabolites for 7-keto-DHEA-acetate in human urine (II). Analytical Science and Technology, 17(5), 401-409.
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Abstract
The 7-keto-DHEA-acetate is converted to 7-keto-DHEA, a metabolite of DHEA, and similar to its metabolism. We studied the metabolite M3, M4, and M5 of 7-keto-DHEA-acetate. The estimated molecular weight of M3 and M4 was 304 which were supposed to have more 3 hydroxyl and/or ketone groups. We could know that M3 is the 7-OH-DHEA which has the hydroxyl groups on 3 and 7-carbon and a ketone group on 17-carbon. In case of M4, it is the 7-oxo- diol metabolite which has the hydroxyl groups on 3 and 17-carbon and a ketone group on 7-carbon. The M5 was supposed that the molecular weight is 320 and has the three hydroxyl groups on 3, 6, and 16 carbon and the ketone group on 17-carbon. After dosing, 7-OH-DHEA showed the maximum urine flow in human urine after 5 hr and decreased rapidly. But we could find it until 58 hr why is a higher remaining substance.
- keywords
- 7-keto-dehydroepiandrosterone-acetate, dosed human urine, metabolite M3, metabolite M4, metabolite M5, LC/ESI/MS, GC/MS
Reference
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