- P-ISSN 1225-0163
- E-ISSN 2288-8985
- Log In/Sign Up
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
Home > Article Detail
A study of the metabolites for 7-keto-DHEA-acetate in human urine (II)
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2004, v.17 no.5, pp.401-409
&
(2004). A study of the metabolites for 7-keto-DHEA-acetate in human urine (II). Analytical Science and Technology, 17(5), 401-409.
- Downloaded
- Viewed
Abstract
The 7-keto-DHEA-acetate is converted to 7-keto-DHEA, a metabolite of DHEA, and similar to its metabolism. We studied the metabolite M3, M4, and M5 of 7-keto-DHEA-acetate. The estimated molecular weight of M3 and M4 was 304 which were supposed to have more 3 hydroxyl and/or ketone groups. We could know that M3 is the 7-OH-DHEA which has the hydroxyl groups on 3 and 7-carbon and a ketone group on 17-carbon. In case of M4, it is the 7-oxo- diol metabolite which has the hydroxyl groups on 3 and 17-carbon and a ketone group on 7-carbon. The M5 was supposed that the molecular weight is 320 and has the three hydroxyl groups on 3, 6, and 16 carbon and the ketone group on 17-carbon. After dosing, 7-OH-DHEA showed the maximum urine flow in human urine after 5 hr and decreased rapidly. But we could find it until 58 hr why is a higher remaining substance.
- keywords
- 7-keto-dehydroepiandrosterone-acetate, dosed human urine, metabolite M3, metabolite M4, metabolite M5, LC/ESI/MS, GC/MS
Reference
1
G. Gordon Gibson, (1999) Introduction to drug metabolism,
2
Kenneth L, , (1998) Mass spectrometry/Mass spectrometry,
3
Raymond E. March, (1995) Practical aspect of ion trap mass spectrometry,
4
Douglas A. S, (1998.) Principles of instrumental analysis,
Other articles from this issue
- Analytical Methods of the Polychlorinated Biphenyls in Waste Transformer Oils
- Determination of lead content in the plastic by ICP and AAS using HI reduction - PbSO4 dissolution method
- Kinetic Analysis by High Pressure and High Vacuum Apparatus for the Nucleophilic Substitution Reaction
- Determination of Tritium in Spent Pressurized Water Reactor (PWR) Fuels
- Structural Studies of Membrane Protein by Solid-state NMR Spectroscopy
- Nitrosation of U.S. E.P.A. Classified Eleven Priority Pollutant Phenols
- A study of the metabolites for 7-keto-DHEA-acetate in human urine (II)
- Studies on the body-retaining rate of smoking-related carcinogens using some important volatile organic compounds (VOC)
- Qualitative Analysis of the Component Materials of Nuclear Power Plant Using Time-Resolved Laser Induced Breakdown Spectroscopy
- Monitoring of Bisphenol A and Nonylphenol in Waterworks System of Seoul, Korea
- Study on the Enhancement of Reproducibility for Track Technology Using a Multi-dot Plate
- Extraction Chromatographic Separation of Technetium-99 from Spent Nuclear Fuels for Its Determination by Inductively Coupled Plasma-Mass Spectrometry
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.