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Structure elucidation and determination of illegal compounds (Anti-impotance drug analogues) in foods
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2008, v.21 no.2, pp.65-83
(2008). Structure elucidation and determination of illegal compounds (Anti-impotance drug analogues) in foods. Analytical Science and Technology, 21(2), 65-83.
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Abstract
It is noted that illegal hazardous foods containing unauthorized drugs or synthetic drung analoguesare increasing. Especially, reported are unknown compounds that have the modified chemical structures of the anti-impotence drugs such as sildenafil, vardenafil, and tatalafil. In addition, it is very reserved, since illegal syntheticcompounds having similar chemical structures modified from anti-impotence drug to avoid the government inspectionare not proved their safety at all. This review in ulation to food safety, lists the illegal compounds added to foodsze 16 anti-impotence drug analogues such as homosildenafil,hongdenafil, pseudovardenafil, aminotadalafil, hydroxyhomosildenafil, hydroxyhongdenafil, dimethylsildenafil, xan-thoanthrafil, hydroxyvardenafil, norneosildenafil, demethylhongdenafil, piperidinohongdenafil, carbodenafil, thiosil-denafil, dimethylthiosildenafil, and acetylvardenafil.
- keywords
- food, anti-impotence drugs, structure elucidation, illegal compound
Reference
1
1. 신종유해물질연구회지, Vol. 1, (행정간행물등록번호;11-1470000-001177-10), 식품의약품안전청, 2006.
2
2. 식품의약품안전청 홈페이지 (http://www.kfda.go.kr).
3
3. 2006년 발기부전치료제 및 유사물질 검출현황 (행정간행물등록번호; 11-1470000-001167 -24), 식품의약품안전청, 2006.
4
4. 오·남용우려의약품지정등에관한규정, 식품의약품안전청 고시 제2005-78호(2005.12.19).
5
5. 식품위생법, 보건복지부 (2005.7).
6
6. 日本厚生勞省 (http://mhlw.go.jp).
7
7. US FDA (http://fda.gov)
8
8. Health Canada (http://www.hc-sc.gc.ca)
9
9. 식품공전, 식품의약품안전청 (2005).
10
10. Elucidation data on Adulterated anti-impotence drugs and their analogues (행정간행물등록번호; 11-1470000-001166-14), 식품의약품안전청, 2006.
11
11. J. Cho, H. Lim, K. Yu, H. Shim, I, Jang, S. Shim, J.Chromatogr. B, 795, 179-186(2003).
12
12. E. Boyce, E. Umland, Clin. Ther., 23, 2-23(2001).
13
13. R. Skoumal, J. Chen, K. Kula, J. BreZa, N. Calomfirescu,B. Basson, V. Kopernicky, Eur. Urol., 46, 362-369(2004).
14
14. J. Mulhall, F. Montorsi, Eur. Urol., 496, 30-37(2006).
15
15. M. Shin, M. Hong, W. Kim, Y. Lee, Y. Jeoung, Food Addit. Contam., 20, 793-796(2003).
16
16. S. Gratz, C. Flurer, K. Wolnik, J. Pharm.Biomed. Anal.,36, 525-533(2004).
17
17. 식품중 발기부전치료제및유사물질 (행정간행물등록번호; 11-1470000-000528-01), 식품의약품안전청,2004.
18
18. 식품 중 부정유해물질분석 매뉴얼 (행정간행물둥록번호; 11-1470000-00839-14), 식품의약품안전청, 2005.
19
19. P. Zou, S. Oh, P. Hou, M. Low and H. Koh, J. Chromatogr.A, 1104, 113-122(2006).
20
20. C. Shin, M. Hong, D. Kim and Y. Lim, Magn. Res.Chem., 42(12), 1060-1062(2004).
21
21. J. Reepmeyer and J. Woodruff, J. Pharm. Biomed.Anal., 44, 887-893(2007).
22
22. J. Reepmeyer and J. Woodruff, J. Chromatogr. A, 1125,67-75(2006).
23
23. H. Park, H. Jeong, M. Chang, M. Im, J. Jeong, D. Choi,K. Park, M. Hong, J. Youm, S. Han, D. Kim, J. Park and S. Kwon, Food Addit. Contam., 24, 122-129(2007).
24
24. e-Letter of New Hazard Chemicals, 1(3), (2006), (http://blog.korea.kr/nhct)
25
25. International Patent, WO 2005/058899 A1, June 30,2005.
26
26. J. Reemeyer, J. Woodruff and D. Andre d'Arignon, J.Pharm. Biomed. Anal., 43, 1615-1621(2007).
27
27. J. Wang, Y. Jiang, Y. Wang, X. Zhou, Y. Cui and J. Gu,J. Pharm. Biomed. Anal., 44, 231-235(2007).
28
28. e-Letter of New Hazard Chemicals, 1(1), (2006), (http://blog.korea.kr/nhct)
29
29. e-Letter of New Hazard Chemicals, 1(7), (2006), (http://blog.korea.kr/nhct)
30
30. US Patent, US 6,566,360 B1, May 20, 2003.
31
31. e-Letter of New Hazard Chemicals, 2(5), (2007), (http://blog.korea.kr/nhct)
32
32. S. Gratz, B. Gamble and R. Flurer, Rapid Commun.Mass Spectrom., 20, 2317-2327(2006).
33
33. J. Kim, H. Ji, S. Kim, H. Lee, S. Lee, D. Kim, M. Yoo,W. Kim and H. Lee, J. Pharm. Biomed. Anal., 32, 317-322(2003).
34
34. International Patent, WO 02/102802 A1, December 27,2002.
35
35. J. Lee, H. Yoo, M. Kang and D. Kim, Rapid Commun. Mass Spectrom., 19, 1767-1770(2005).
36
36. R. Silverstein, G. Bassler and T. Morril, “Spectrometric Identification of Organic Compounds“, 4th Ed, John Wiley & Sons, 1981.
37
37. F. McLafferty, “Interpretation of Mass Spectra”, 3th Ed, University Science Books, 1980.
38
38. KFDA Library of IR, MS & NMR Spectra - Anti-impotence Drugs and Analogues (행정간행물등록번호; 11-1470000-000881-14), 식품의약품안전청, 2005.
39
39. 명승운, 박서희, 조현우, 분석과학, 16, 488-498(2003).
40
40. 최현철, 강신정, 윤미옥, 박상애, 김호정, 위세승, 김자연, 차기원, 분석과학, 16, 32-38(2003).
41
41. 장재희, 박건상, 박혜경, 구용의, 최윤주, 황인경, 김대병, J. Fd. Hyg. Safety, 18, 177-182(2003).
42
42. 최동미, 임무혁, 이경진, 권광일, 정지윤, 박건상, 홍무기, 이철원, 분석과학, 17, 520-526(2004).
43
43. D. Zhong, J. Xing, S. Zhang and L. Sun, Rapid Commun.Mass Spectrom., 16, 1836-1843(2002).
44
44. M. Sheu, A. Wu, G. Yeh, A. Hsia, H. Ho and Y.Jeoung, J. Chromatogr. B, 791, 255-262(2003).
45
45. X. Zhu, S. Xiao, B. Chen, F. Zhang, S. Yao, Z. Wan, D.Yang and H. Han, J. Chromatogr. A, 1066, 89-95 (2005).
46
46. E. Mikami, T. Ohno and H. Matsumoto, Forensic Sci.,Int., 130 140-146(2002).
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