- P-ISSN 1225-0163
- E-ISSN 2288-8985
- Apply for Authority
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
Home > Article Detail
Determination of acidic pharmaceuticals in aquatic environmental samples by LC/ESI-MS/MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2008, v.21 no.3, pp.191-200
&
(2008). Determination of acidic pharmaceuticals in aquatic environmental samples by LC/ESI-MS/MS. Analytical Science and Technology, 21(3), 191-200.
- Downloaded
- Viewed
Abstract
의약물질(PPCPs)은 수질 환경 시료에서 새로운 오염물질로 대두되고 있다. 본 연구에서는 LC/ ESI-MS/MS를 이용하여 환경 수질 시료로부터 7 종(2-퀴노사린카르복시산, 아세틸살리실산, 디클로페낙- 소듐, 나프록센, 이부프로펜, 메페남산, 탈니플루메이트)의 산성의약물질을 동시 분석하는 방법을 비교하 여 개선하였으며 폐수처리장의 유입수 및 방류수 그리고 연장선상의 하천수의 오염도를 측정하였다. LC/ ESI-MS/MS 분석을 위해서 MCX (Mixed Cation eXchange) 카트리지와 HLB (Hydrophilic-Lipophilic Balance) 카트리지를 연결하는 텐뎀 고체상 추출법과 MCX 카트리지만을 사용하는 고체상 추출법을 이 용하여 효과적인 시료 정제 및 추출을 수행하였다. 검출한계(LODs)와 방법검출한계(MDLs)는 각각 0.05 ~1.50 pg/mL, 0.17~4.90 pg/mL 범위를 나타내었다. 시료 중 1.0 ng/mL 농도(n=3)에서 절대 회수율은 81.9% ~116.3%를 나타내었다. 수질 환경 시료에서 수 pg/mL~ng/mL의 농도로 산성의약물질이 측정되었다.
- keywords
- acidic pharmaceuticals, aquatic environmental samples, LC/ESI-MS/MS
Reference
1
1. S. J. Khan and J. E. Ongerth, Chemosphere, 54, 355-367(2004).
2
2. Environmental Risk Assessment for Veterinary Medicinal Products other than GMO-containing and Immunological Products, EMEA, London (EMEA/CVMP/055/96)(1998).
3
3. J. V. Holm, K. Rugge, P. L. Bjerg and T. H. Christensen,Environ. Sci. Technol., 29, 1415-1420(1995).
4
4. H. G. Choi and H. W. Jun J. Pharmaceut. Biomed. Anal.,35, 221-231(2004).
5
5. V. M. Johnson, J. P. Allanson and R. C. Causon, J.Chromatogr. B, 740, 71-80(2000).
6
6. D. Loffler and T. A. Ternes, J. Chromatogr. A, 1021,133-144(2003).
7
7. B. J. Vanderford, R. A. Pearson, D. J. Rexing and S. A.Snyder, Anal. Chem., 75, 6265-6268(2003).
8
8. L. Araujo, J. Wild, N. Vila, N. Camargo, D. Cubillan and A. Prieto, Talanta, 75, 111-115(2008).
9
9. B. Kasprzyk-Hordern, R. M. Dinsdale and A. J. Guwy,Talanta, 74, 1299-1312(2008).
10
10. G. H. Han and H. G. Hur and S. D. Kim, Environ. Toxicol.Chem., 25, 265-266(2006).
11
11. D. Fatta and Nikolaou, Trends Anal. Chem., 26, 515-533(2007).
12
12. M. J. Hutchinson, P. B. Young and D. G. Kennedy J.Chromatogr. B, 816, 16-17(2005).
13
13. K. G. Karthikeyan, Sci. Tot. Environ., 361, 196-207(2006).
14
14. D. Lffler, J. Chromatogr. A, 1021, 133-144(2003).
15
15. J. B. Quintana and T. Reemtsma, Rapid Commun. Mass Spectrom., 18, 765-774(2004).
16
16. W. W. Buchberger, Anal. Chim. Acta, 593, 129-139(2007).
17
17. S. Zuhlke, U. Dunnbier and T. Heberer, J. Chromatogr.A, 1050, 201-209(2005).
Other articles from this issue
- It's effects for engine emission of water/oil emulsified fuel
- The removal characteristics of PCB by catalyzed fabric filter
- Rapid analytical method of the polychlorinated biphenyls in PCBs containing liquid wastes
- The survey of exposure level for PFOS and PFOA in human plasma from several residential areas in Korea
- Determination of acidic pharmaceuticals in aquatic environmental samples by LC/ESI-MS/MS
- Determination of byproducts after treatment in PCBs-containing transformer oils
- Study on fatty acids composition by latent fingerprint deposition
- Developing of latent fingerprint on human skin
- Preparation and photocatalytic effect of MWCNT/TiO2 composites
- Preparation of ZnO@TiO2 nano coreshell structure by the polymerized complex and sol-gel method
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.