- P-ISSN 1225-0163
- E-ISSN 2288-8985
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
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Determination of acidic pharmaceuticals in aquatic environmental samples by LC/ESI-MS/MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2008, v.21 no.3, pp.191-200
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(2008). Determination of acidic pharmaceuticals in aquatic environmental samples by LC/ESI-MS/MS. Analytical Science and Technology, 21(3), 191-200.
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Abstract
의약물질(PPCPs)은 수질 환경 시료에서 새로운 오염물질로 대두되고 있다. 본 연구에서는 LC/ ESI-MS/MS를 이용하여 환경 수질 시료로부터 7 종(2-퀴노사린카르복시산, 아세틸살리실산, 디클로페낙- 소듐, 나프록센, 이부프로펜, 메페남산, 탈니플루메이트)의 산성의약물질을 동시 분석하는 방법을 비교하 여 개선하였으며 폐수처리장의 유입수 및 방류수 그리고 연장선상의 하천수의 오염도를 측정하였다. LC/ ESI-MS/MS 분석을 위해서 MCX (Mixed Cation eXchange) 카트리지와 HLB (Hydrophilic-Lipophilic Balance) 카트리지를 연결하는 텐뎀 고체상 추출법과 MCX 카트리지만을 사용하는 고체상 추출법을 이 용하여 효과적인 시료 정제 및 추출을 수행하였다. 검출한계(LODs)와 방법검출한계(MDLs)는 각각 0.05 ~1.50 pg/mL, 0.17~4.90 pg/mL 범위를 나타내었다. 시료 중 1.0 ng/mL 농도(n=3)에서 절대 회수율은 81.9% ~116.3%를 나타내었다. 수질 환경 시료에서 수 pg/mL~ng/mL의 농도로 산성의약물질이 측정되었다.
- keywords
- acidic pharmaceuticals, aquatic environmental samples, LC/ESI-MS/MS
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