- P-ISSN 1225-0163
- E-ISSN 2288-8985
- Log In/Sign Up
- P-ISSN1225-0163
- E-ISSN2288-8985
- SCOPUS, ESCI, KCI
Article Detail
Home > Article Detail
Development of alternative titration method without mercuric acetate for the assay of difemerine hydrochloride in Korean Pharmaceutical Codex
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2014, v.27 no.4, pp.196-200
https://doi.org/10.5806/AST.2014.27.4.196
&
(2014). Development of alternative titration method without mercuric acetate for the assay of difemerine hydrochloride in Korean Pharmaceutical Codex. Analytical Science and Technology, 27(4), 196-200, https://doi.org/10.5806/AST.2014.27.4.196
- Downloaded
- Viewed
Abstract
Currently nonaqueous titration method for the assay method using the hazardous reagent, mercuryacetate for difemerine hydrochloride has been used in Korean Pharmaceutical Codex. We developed analternative titration assay method by substituting the use of the hazardous reagent, mercury acetate to the useof less toxic ones like ethyl alcohol. The linearity of the calibration curves in the desired concentration rangewas good (r>0.999). Precision was less than 0.64%. Accuracy was obtained with recoveries in range of 99.10%and 99.71%. The developed assay could be expected to become valuable tools for revising the KoreanPharmaceutical Codex.
- keywords
- Korean Pharmaceutical Codex, hazardous reagents, alternative testing methods, validation, titration
Reference
1
1. ICH Guideline. Q3C(R4) : Impurities : Guideline for residual solvents Q3C(R4) in ICH harmonised tripartite guideline (2009).
2
2. K. Alfonsi, J. Colberg, P. J. Dunn, T. Fevig, S. Jennings, T. A. Johnson, H. P. Kleine, C. Knight, M. A. Nagy, D. A. Perry and M. Stefaniak, Green Chem., 10, 31-36(2008).
3
3. Ministry of Food and Drug Safety, 11-1470000-002440-01, 56, 2, Republic of Korea (2011).
4
4. Ministry of Food and Drug Safety No. 2012-142, Republic of Korea (2012).
5
5. Ministry of Food and Drug Safety, No. 2012-129, 1368, Republic of Korea (2012).
6
6. S. Budauari, Merck index 13th ed., Merck & Co., Inc (2001).
7
7. Difemerine HCl, http://www.health.kr/drug_info/basedrug/list.asp, Assessed 18 Jul (2014).
8
8. JEF. Reynolds, Martindale the extra pharmacopoeia 13th Ed., Pharmaceutical press (1993).
9
9. Ministry of Food and Drug Safety No. 2009-173, Republic of Korea (2009).
10
10. Ministry of Food and Drug Safety No. C0-2012-2-005, Republic of Korea (2012).
Other articles from this issue
- Amperometric detection of hydrogen peroxide at an azalea peroxidase embedded enzyme electrode
- Enhancement of cyanoacrylate-developed marks using p-dimethylaminobenzaldehyde (DMAB) on semi-porous surfaces and analysis of the influence factors on fluorescence intensity
- Development of alternative titration method without mercuric acetate for the assay of difemerine hydrochloride in Korean Pharmaceutical Codex
- Study on analysis of PAHs in consumer products
- Compositions of haze aerosols and their variation by inflow pathway of air mass at Gosan site in Jeju Island during 2012-2013
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.