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Quantitative determination of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)- furanone (MX) in chlorinated drinking water using sample enrichment followed by liquid-liquid extraction and GC-MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2016, v.29 no.1, pp.29-34
https://doi.org/10.5806/AST.2016.29.1.29
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(2016). Quantitative determination of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)- furanone (MX) in chlorinated drinking water using sample enrichment followed by liquid-liquid extraction and GC-MS. Analytical Science and Technology, 29(1), 29-34, https://doi.org/10.5806/AST.2016.29.1.29
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Abstract
This study explores the means by which MX can be effectively extracted from chlorinated water 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a potent mutagen commonly found in chlorinated drinking water at concentrations of up to a few hundred ng/L, was quantitatively determined using sample enrichment followed by liquid-liquid extraction (LLE), derivatization to methylated form, and analysis with GC-MS. A 4-L water sample was enriched to a concentration of 0.4 L using a vacuum rotary evaporator at 30 oC. MX in the water was extracted using ethyl acetate (100 mL × 2) as a solvent and MX in the extract was methylated with 10% H2SO4 in methanol. MX was recovered at a rate of 73.8 %, which was higher than that (38.1 %) for the resin adsorption method. The limit of quantification and repeatability (as relative standard deviation) were estimated to be 10 ng/L and 2.2%, respectively. This result suggested that LLE can be used for the determination of MX in chlorinated water as an alternative to more time-consuming resin adsorption method.
- keywords
- chlorinated drinking water, GC-MS, liquid-liquid extraction, MX, sample enrichment
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