- P-ISSN 1225-0163
- E-ISSN 2288-8985
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- P-ISSN1225-0163
- E-ISSN2288-8985
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The distribution of <TEX>$^{14}C$</TEX>-warfarin and the purification of hepatic microsome induced isozymes with coumarin
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1992, v.5 no.1, pp.83-90
Park,
S., Kim,
E., Min,
J., You,
J., Lee,
H., Seo,
B., &
Han,
W.
(1992). The distribution of <TEX>$^{14}C$</TEX>-warfarin and the purification of hepatic microsome induced isozymes with coumarin. Analytical Science and Technology, 5(1), 83-90.
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Abstract
The <TEX>$^{14}C$</TEX>-warfarin used as rodenticids was identified from various organs of sprague dawley with scintillation counter. And the cytochrome p-450 which was induced by coumarin derivatives was identified with electrophoresis. The distributions of <TEX>$^{14}C$</TEX>-warfarin after <TEX>$14.8{\mu}Ci/kg$</TEX> oral application at each organ was as follows; urine-7.5%, blood-0.44%, feces-0.9%, liver-0.66%, lung-0.86%, kidney-0.8%, heart-0.43% and spreen-0.33% after 24hrs. The cytochrome p-450 was purified by Octyl Sepharose CL-4B hydrophobic chromatography and isozymes were 50.8 Kd in control group, 53.3 Kd and 55.2 Kd in coumarin pretreated group and 50.8 Kd, 54.6 Kd and 57.7 Kd in warfarin pretreated group.
- keywords
- <TEX>$^{14}C$</TEX>-warfarin, cytochrome p-450, hepatic microsome
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