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Microanalysis of Vecuronium Bromide in Biological Fluids by Spectrofluorimetry and HPLC-Fluorescence Detection
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1994, v.7 no.3, pp.413-419
Ko,
Y., Han,
S., Shin,
T., An,
N., &
Ock,
C.
(1994). Microanalysis of Vecuronium Bromide in Biological Fluids by Spectrofluorimetry and HPLC-Fluorescence Detection. Analytical Science and Technology, 7(3), 413-419.
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Abstract
The determination of the neuromuscular blocking agents vecuronium bromide(VeBr) in biological fluids has been investigated. The method depends on the formation of insoluble red complex between vecuronium bromide and rose bengal in aqueous layer. The amount of vecuronium bromide was calculated from that of extracted rose bengal which was determined by spectrofluorimetry or HPLC/fluorescence detection method. It was possible to analyze VeBr in the range of <TEX>$2{\sim}32{\mu}g/ml$</TEX>(r
- keywords
- Vecuronium bromide, Rose bengal, Spectrofluorimetry, HPLC analysis
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