- P-ISSN 1010-0695
- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Genetic Polymorphism of CCK Promotor Region and Sasang Constitution
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.3, pp.105-110
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(2004). Genetic Polymorphism of CCK Promotor Region and Sasang Constitution. Journal of Korean Medicine, 25(3), 105-110.
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Abstract
Objectives : :Sasang Constitutional Medicine is based on the diversity of human being and medically developed the variation of response to diseases and medicines. The diversity is categorized as four from morphology, physiology, pathology, pharmacology. So it is supposed that Sasang Constitutional Medicine is related the genetic diversity of individuals. Single nucleotide polymorphism is the basic tool to research genetic polymorphism as a landmark of genome. Each constitution has different processes of pathopysiology and metabolisms to herb medications. In clinical research, the stroke incidence is significantly different by constitution. Methods : We researched whether the polymorphic expression of CCK (rs=2241997) is depending on Sasang Constitution. It was investigated that [c／t] polymorphism site of promotor region of CCK gene on 3p22-p21.3 Results : The allele frequency of [c/t] polymorphism of CCK promotor region was different in constitution groups compared the average allele frequency of SNP DB. The allele frequencies of Soeumin and Soyangin groups were (c:0.70/t:0.30)，(c:0.71/t:0.29) and that of Taeumin group was (c:0.57/t:0.43) and Taeyangin groups were (c:1.00/t:0.00) Conslusions : It was regarded the [c/t] polymorphism of CCK promotor region is available to classify the constitution. But it is necessary to research about CCK gene polymorphism and more constitution population group. And it is also necessary to research the more funtional gene's polymorphism and sasang constitution
- keywords
- Sasang Constitution, Polymorphism, CCK, SNP, Sasang Constitution, Polymorphism, CCK, SNP
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