ACOMS+ 및 학술지 리포지터리 설명회

  • 한국과학기술정보연구원(KISTI) 서울분원 대회의실(별관 3층)
  • 2024년 07월 03일(수) 13:30
사전등록 바로가기
 

논문 상세

Home > 논문 상세
  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

이전

다음

25권 3호
Share

사상체질의 Cholecystokinin 유전자 단일염기다형성 연구

Genetic Polymorphism of CCK Promotor Region and Sasang Constitution

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2004, v.25 no.3, pp.105-110
이수경 (경희대학교)
이성진 (아산생명과학연구소)
이수경, & 이성진. (2004). 사상체질의 Cholecystokinin 유전자 단일염기다형성 연구. 대한한의학회지, 25(3), 105-110.
  • 다운로드 수
  • 조회수

Abstract

Objectives : :Sasang Constitutional Medicine is based on the diversity of human being and medically developed the variation of response to diseases and medicines. The diversity is categorized as four from morphology, physiology, pathology, pharmacology. So it is supposed that Sasang Constitutional Medicine is related the genetic diversity of individuals. Single nucleotide polymorphism is the basic tool to research genetic polymorphism as a landmark of genome. Each constitution has different processes of pathopysiology and metabolisms to herb medications. In clinical research, the stroke incidence is significantly different by constitution. Methods : We researched whether the polymorphic expression of CCK (rs=2241997) is depending on Sasang Constitution. It was investigated that [c／t] polymorphism site of promotor region of CCK gene on 3p22-p21.3 Results : The allele frequency of [c/t] polymorphism of CCK promotor region was different in constitution groups compared the average allele frequency of SNP DB. The allele frequencies of Soeumin and Soyangin groups were (c:0.70/t:0.30)，(c:0.71/t:0.29) and that of Taeumin group was (c:0.57/t:0.43) and Taeyangin groups were (c:1.00/t:0.00) Conslusions : It was regarded the [c/t] polymorphism of CCK promotor region is available to classify the constitution. But it is necessary to research about CCK gene polymorphism and more constitution population group. And it is also necessary to research the more funtional gene's polymorphism and sasang constitution

keywords
Sasang Constitution, Polymorphism, CCK, SNP, Sasang Constitution, Polymorphism, CCK, SNP


참고문헌

1

조황성, (1998) 사상체질과 유전학,

2

조동욱, (1996) 유전자 지문법을 이용한 사상체질의 유전적 분석 연구,

3

조동욱, (1998) Amp-FLP을 이용한 사상체질의 유전적 분석 연구,

4

김민희, (1999) 유전적 분석법에 의한 사상체질의 연구,

5

최승훈, (1998) 사상체질유형과 ACE 유전자 Type과의 상관관계,

6

주종천, (2002) 뇌경색 환자의 안지오텐신 전환 효소 유전자 다형성과 사상체질,

7

하만수, (2002) 사상체질과 HLA type과의 상관성에 관한 연구,

8

Pui-Yan Kwok,, (1994) Comparative Analysis of Human DNA Variations by Fluorescence-Based Sequencing of PCR Products,

9

Takahashi, Y.;, (1996) Structure of human cholecystokinin gene and its chromosomal locati Owyang C. Physiological mechanisms of cholecystokinin action on pancreatic secretion,

10

Hansen TV, (2000) Function of the C-36 to T polymorphism in the human cholecystokinin gene promoter,

11

Bradwejn J,, (2001) Cholecystokinin and panic disorder: past and future clinical research strategies.,

12

Wang Z, (2002) Possible association of a cholecystokinin promoter variant to schizophrenia,

13

Fujii C,, (1999) Association between polymorphism of the cholecystokinin gene and idiopathic Parkinson's disease,

14

Fujii C,, (1999) Association between polymorphism of the cholecystokinin gene and idiopathic Parkinson's disease,

  • 다운로드 수
  • 조회수
  • 0KCI 피인용수
  • 0WOS 피인용수

권호 내 다른 논문

추천 논문

상단으로 이동

권호 목록

소개

규정 및 지침

게시판

대한한의학회지

  학술지 홈페이지 이용 환경은   크롬 브라우저 사용을 권장합니다.

대한한의학회지

논문 투고 OA 정책