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- E-ISSN 2288-8985
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Retention Behavior and Separation of Phenol Derivatives through Cyclodextrin Complexes in Reversed-Phase Liquid Chromatography
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
1998, v.11 no.3, pp.179-188
Moon,
Y., &
Kang,
S.
(1998). Retention Behavior and Separation of Phenol Derivatives through Cyclodextrin Complexes in Reversed-Phase Liquid Chromatography. Analytical Science and Technology, 11(3), 179-188.
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Abstract
The capacity factor of fifteen phenol derivatives was determined with respect to the concentration of <TEX>${\alpha}$</TEX>- or <TEX>${\beta}$</TEX>-cyclodextrin [CD], the type as well as the content of organic solvent in the mobile phase, and the temperature. The effect of the inclusion complex formation between solutes and <TEX>${\alpha}$</TEX>- or <TEX>${\beta}$</TEX>-cyclodextrin on their retention and selectivity has been investigated. The inclusion effect of <TEX>${\beta}$</TEX>-cyclodextrin was the most effective in aqueous methanol, whereas only a poor effect was observed in aqueous tetrahydrofuran and aqueous acetonitrile. A plot of the reciprocal of the capacity factor against <TEX>$[CD]_T$</TEX> gives a straight line and the dissociation constant, <TEX>$K_D$</TEX> of the inclusion complex can be calculated from the slope. It was possible to estimate the <TEX>$k_D$</TEX> values in 100% water from a linear plot of <TEX>$pK_D$</TEX> vs. water content in the solution by extrapolation. The separation factor, <TEX>${\alpha}$</TEX>, of two compounds has been found to be affected not only by the <TEX>$[CD]_T$</TEX> but also by their <TEX>$K_D$</TEX> values. Under optimum conditions, some mixtures of phenol derivatives were able to separate successfully.
- keywords
- Cyclodextrin, Phenol, Liquid chromatography
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