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- E-ISSN 2288-8985
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- P-ISSN1225-0163
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Constructing Database for Drugs and its Application to Biological Sample by HPTLC and GC/MS
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2000, v.13 no.2, pp.136-150
Yoo,
Y., Park,
S., Lim,
M., Baeck,
S., Park,
S., Lee,
J., &
Lho,
D.
(2000). Constructing Database for Drugs and its Application to Biological Sample by HPTLC and GC/MS. Analytical Science and Technology, 13(2), 136-150.
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Abstract
For the identification of unknown drugs in biological samples, we attempted rapid high performance thin layer chromatographic method which is sensitive and selective chromatographic analysis of high performance thin layer chromatography (HPTLC) with automated TLC sampler and ultra-violet (UV) scanner. We constructed HPTLC database (DB) on two hundred five drugs by using the data of Rf values and UV spectra (scan 200-360 nm) as well as gas chromatography/mass spectrometry (GC/MS) DB on ninety six drugs by using the data of relative retention time (RRT) on lidocain and mass spectra. After extracting drugs in biological sample by solid phase extraction (Clean Screen ZSDAU020), we applied them to HPTLC and GC/MS DB. Drugs, especially extracted from biological samples, showed good matching ratio to HPTLC DB and these drugs were confirmed by GC/MS. In conclusion, this DB system is thought to be very useful method for the screening of unknown drugs in biological samples.
- keywords
- Database, Drugs, HPTLC, GC/MS
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