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Toxic Evaluation and Chromatographic Analysis of Cucurbitacin D and F from Sorbaria sorbifolia
Analytical Science and Technology / Analytical Science and Technology, (P)1225-0163; (E)2288-8985
2001, v.14 no.2, pp.191-195
Lee,
S., &
Lee,
C.
(2001). Toxic Evaluation and Chromatographic Analysis of Cucurbitacin D and F from Sorbaria sorbifolia. Analytical Science and Technology, 14(2), 191-195.
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Abstract
Cucurbitacin D and F, the protostane type triterpenoid of S. sorbifolia, were isolated with chromatograpic method and used as the standard substances for quantitative analysis. The compounds were identified with <TEX>$^1H$</TEX>-NMR, FAB-MS and UV spectrophotometer. They were separated on YMC-Pack ODS-AQ(303)[<TEX>$250{\times}4.6mm$</TEX> I.D., <TEX>$S-5{\mu}m$</TEX>, 120A] column by HPLC. Cucurbitacin F was detected at 10.73mg/kg in cortex of S. sorbifolia, but cucurbitacin D was not. The compounds were shown to exihibit significant cytotoxicity(<TEX>$ED_{50}$</TEX><<TEX>$0.1{\mu}g/mL$</TEX>) against several tumor cell lines and acute toxicity(cucurbitacin D: 4.7mg/kg/day, cucurbitacin F: 2.5mg/kg/day) against BDF-1 mouse.
- keywords
- Sorbaria sorbifolia, cucurbitacin D, cucurbitacin F, toxicity
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